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holothurin A

RN given refers to Na salt (3 beta,12 alpha,22S)-isomer

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Holothurin: 5
      - holothurin A: 4
Biological Factors: 2472
- Biological Toxins: 20
  - Marine Toxins: 124
    - Holothurin: 5
      - holothurin A: 4

Experts

1.	Chaithirayanon, Kulathida: 1 article (09/2021)
2.	Garon, Arthur: 1 article (09/2021)
3.	Janta, Sirorat: 1 article (09/2021)
4.	Langer, Thierry: 1 article (09/2021)
5.	Plubrukarn, Anuchit: 1 article (09/2021)
6.	Pranweerapaiboon, Kanta: 1 article (09/2021)
7.	Seidel, Thomas: 1 article (09/2021)
8.	Dong, Ping: 1 article (01/2014)
9.	Hu, Xiaoqian: 1 article (01/2014)
10.	Liu, Chunhua: 1 article (01/2014)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2022 - "Targeting alternatives sites on the surface of AR via holothurin A will provide a potential candidate for future prostate cancer treatment.Communicated" 01/01/2022 - "In vitro and in silico studies of holothurin A on androgen receptor in prostate cancer." 01/01/2022 - "Holothurin A reduced the PSA expression, leading to the growth inhibition of androgen sensitive prostate cancer cell line through a downregulation of AR activity. " 06/03/2023 - "Holothurin A Inhibits RUNX1-Enhanced EMT in Metastasis Prostate Cancer via the Akt/JNK and P38 MAPK Signaling Pathway." 01/01/2022 - "Herein, we investigate the potential of using a marine triterpenoid saponin, holothurin A, on targeting AR expression of prostate cancer using in vitro and in silico studies. "
2.	Obesity 01/01/2014 - "Two similarly sulfated triterpene saponins from Pearsonothuria graeffei were prepared to investigate the anti-obesity effects of echinoside A (EA) and holothurin A (HA). " 01/01/2014 - "Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction."
3.	Neoplasm Metastasis (Metastasis) 06/03/2023 - "Holothurin A Inhibits RUNX1-Enhanced EMT in Metastasis Prostate Cancer via the Akt/JNK and P38 MAPK Signaling Pathway."
4.	Hemolysis 08/01/1964 - "HEMOLYSIS BY HOLOTHURIN A, DIGITONIN, AND QUILLAIA SAPONIN: ESTIMATES OF THE REQUIRED CELLULAR LYSIN UPTAKES AND FREE LYSIN CONCENTRATIONS."

Related Drugs and Biologics

1.	Saponins
2.	Triterpenes
3.	Androgen Receptors (Androgen Receptor)
4.	p38 Mitogen-Activated Protein Kinases
5.	Digitonin
6.	Dietary Fats (Dietary Fat)
7.	Androgens
8.	echinoside A