antilipopolysaccharide factor (Limulus)

potent anticoagulant which inhibits the endotoxin-mediated activation of Limulus coagulation system; MW appr. 10,000

Also Known As:

ENP Limulus; Limulus anti-LPS; Limulus anti-LPS factor; Tachypleus anti-LPS factor; anti-LPS (Limulus); anti-lipopolysaccharide factor (Limulus); endotoxin-neutralizing protein, Limulus

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        antilipopolysaccharide factor (Limulus): 4
  - Arthropod Proteins: 21
    - antilipopolysaccharide factor (Limulus): 4
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - antilipopolysaccharide factor (Limulus): 4
  - Antimicrobial Cationic Peptides: 414
    - antilipopolysaccharide factor (Limulus): 4

Experts

1.	Araña, M J: 2 articles (10/2004 - 02/2003)
2.	Garay, H: 2 articles (10/2004 - 02/2003)
3.	Reyes, O: 2 articles (10/2004 - 02/2003)
4.	Vallespi, Maribel G: 2 articles (10/2004 - 02/2003)
5.	Andrä, Jörg: 1 article (09/2007)
6.	Bartels, Rainer: 1 article (09/2007)
7.	Brandenburg, Klaus: 1 article (09/2007)
8.	Garidel, Patrick: 1 article (09/2007)
9.	Gutsmann, Thomas: 1 article (09/2007)
10.	Howe, Jörg: 1 article (09/2007)

Related Diseases

1.	Sepsis (Septicemia) 10/01/2004 - "Differential regulation of Th1/Th2 in relevant tissues for sepsis pathogenesis with a Limulus anti-LPS factor-derived peptide increases survival in Gram-positive sepsis." 10/01/2004 - "In this study, we examined the effect of a Limulus anti-LPS factor (LALF)-derived peptide on lung and liver Th1/Th2 cytokine mRNA levels during a Gram-positive sepsis. "
2.	Septic Shock (Toxic Shock Syndrome) 09/01/2007 - "On the basis of formerly investigated peptides corresponding to the endotoxin-binding domain from LALF [Limulus anti-LPS (lipopolysaccharide) factor], a protein from Limulus polyphemus, we have designed and synthesized peptides of different lengths with the aim of obtaining potential therapeutic agents against septic shock syndrome. "
3.	Shock 02/01/2003 - "We previously observed that a cyclic peptide derived from the Limulus anti-LPS factor (LALF), which partially protect mice from endotoxic shock lethality, has the ability to modulate cytokine secretion in vitro. "
4.	Infections 02/01/2003 - "A Limulus anti-LPS factor-derived peptide modulates cytokine gene expression and promotes resolution of bacterial acute infection in mice."
5.	Bacterial Infections (Bacterial Infection) 09/01/1993 - "Limulus anti-LPS factor (LALF) binds LPS tightly, and, in animal models, reduces mortality when administered before or after LPS challenge or bacterial infection. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Cytokines
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Cyclic Peptides
6.	Lipopolysaccharides
7.	Endotoxins
8.	factor A