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RP 40749
structure given in first source
Also Known As:
2-methylaminocarbothioyl-2-(pyridyl)-2-tetrahydrothiophene; 40749 RP; N-methyl-2-(2-pyridyl)-2,3,4,5-tetrahydro-2-thiophene carbothioamide; RP-40749; 2-Thiophenecarbothioamide, tetrahydro-N-methyl-2-(2-pyridinyl)-
Networked:
6
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiophenes: 257
RP 40749: 6
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Thiophenes: 257
RP 40749: 6
Related Diseases
1.
Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison)
06/01/1986 - "
The efficacy of a new gastric antisecretory drug, 40749 RP, was studied in five cases of Zollinger-Ellison syndrome.
"
06/01/1986 - "
[Treatment of gastric acid hypersecretion in the Zollinger-Ellison syndrome with a thioamide derivative (40749 RP).
"
2.
Duodenal Ulcer (Curling's Ulcer)
05/01/1986 - "
Eleven patients with an endoscopically proven duodenal ulcer received 100 mg of 40749 RP at 8 PM for 3 wk and thereafter a placebo for an additional 3 wk study period.
"
07/01/1985 - "
Eighteen patients with active duodenal ulcer were treated with a novel antisecretory drug, RP 40749, either 100 mg or 150 mg as a daily nocturnal dose for 28 days.
"
04/07/1984 - "
RP 40749 in treatment of duodenal ulcer.
"
04/01/1986 - "
Effects of single daily doses of a pyridil-2-tetrahydrothiophene derivative (40749 RP) on 24 hour H+ activity, nocturnal acid output, gastrin and pepsinogen I profiles in duodenal ulcer patients.
"
07/01/1985 - "
Influence of RP 40749 on basal and meal-stimulated serum-gastrin, serum-pepsinogen I, and gastrin-content of the antral mucosa in duodenal ulcer patients.
"
3.
Peptic Ulcer (Peptic Ulcers)
05/01/1986 - "
Acute and chronic 24-hour gastric pH and pharmacokinetic studies with a long acting antisecretory drug (40749 RP) in peptic ulcer.
"
02/01/1984 - "
These results showed that 40749 RP is a potent antisecretory drug which could be of benefit in the treatment of peptic ulcer disease.
"
4.
Ulcer
07/01/1985 - "
All nine patients receiving 150 mg RP 40749 and eight of nine patients receiving 100 mg RP 40749 healed their ulcers completely within 28 days, becoming rapidly symptom-free after an average of three days.
"
5.
Duodenitis
06/01/1986 - "
In two cases, chronic duodenitis disappeared with 40749 RP only.
"
Related Drugs and Biologics
1.
Pepsinogen A (Pepsinogen)
2.
Gastrins
3.
Thioamides
4.
Acids
5.
Antral