pancreatic spasmolytic polypeptide

from porcine pancreas; spasmolytic activity & inhibitor of gastrointestinal motility & gastric acid secretion; human SML1/hSP is 76% homologous to pig PSP & linked to breast cancer marker gene BCEI/pS2; RN refers to pig PSP; member of trefoil peptide family; 106 AA residues, MW 11700

Also Known As:

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 04/24/1989 - "Growth stimulatory effect of pancreatic spasmolytic polypeptide on cultured colon and breast tumor cells." 01/01/1991 - "Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma." 11/01/1991 - "The bovine pancreatic spasmolytic polypeptide gene maps to syntenic group U10: implications for the evolution of the human breast cancer estrogen inducible locus." 10/19/1989 - "Revised amino acid sequence of pancreatic spasmolytic polypeptide exhibits greater similarity with an inducible pS2 peptide found in a human breast cancer cell line." 06/19/1989 - "'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins)."
2.	Carcinoma (Carcinomatosis) 01/01/1991 - "Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma." 04/24/1989 - "The effects of a novel polypeptide, pancreatic spasmolytic polypeptide (PSP) on a colon carcinoma cell line (HCT 116) were examined. "
3.	Neoplasms (Cancer) 11/01/1991 - "Recently, homology has been reported for pS2, a protein expressed in many human breast cancers, and a hormonogastric protein known as pancreatic spasmolytic polypeptide (SPP; formerly designated as PSP). "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Complementary DNA (cDNA)
4.	Proteins (Proteins, Gene)
5.	Mitogens
6.	Estrogens (Estrogen)
7.	Culture Media
8.	Amino Acids