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aurovertin B

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Aurovertins: 5
      - aurovertin B: 5

Experts

1.	Grover, Gary J: 2 articles (01/2008 - 01/2008)
2.	Chen, Yan: 1 article (01/2020)
3.	Li, Minwei: 1 article (01/2020)
4.	Shan, Weiguang: 1 article (01/2020)
5.	Wo, Jianer: 1 article (01/2020)
6.	Wu, Rui: 1 article (01/2020)
7.	Yang, Xi: 1 article (01/2020)
8.	Yu, Wenyan: 1 article (01/2020)
9.	Zhan, Zhajun: 1 article (01/2020)
10.	Zhao, Hong: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "The potent anti-tumor activity of aurovertin B was further verified in a human MDA-MB-231 xenograft mouse model." 04/01/2008 - "This study showed aurovertin B can be used as an antitumorigenic agent and may be exploited in cancer chemotherapy." 01/01/2018 - "It is completely a novel role for aurovertin B to target tumor cells to death mediated by NK cells and our findings indicate aurovertin B may deserve further development as sensitizing agent in NK cell mediated cancer immunotherapy." 01/01/2018 - "Here we report one natural compound aurovertin B from basidiomycete Albatrellus confluens significantly stimulates the expression of NKG2D ligands on tumor cells, which greatly sensitizes its recognition and lysis by NK cell. "
2.	Ischemia 01/01/2008 - "Based on studies with the nonselective (inhibit both synthase and hydrolase activity) inhibitors aurovertin B and oligomycin B reduce the rate of ATP depletion during ischemia, showing that IF-1 does not completely block hydrolase activity. " 01/01/2008 - "This "inefficient" hydrolysis of ATP consumes 90% of ATP consumed during ischemia as shown with non-selective ATPase inhibitors oligomycin and Aurovertin B. "
3.	Triple Negative Breast Neoplasms 01/01/2020 - "However, very little is known about the in vivo antitumor activity of aurovertin B and the possible mechanism of the selective effect on triple-negative breast cancer cells. " 01/01/2020 - "Aurovertin B, a natural compound from Calcarisporium arbuscular, exhibits potent antiproliferative activity particularly against triple-negative breast cancer cells (TNBC), while having less cytotoxicity on normal breast cell MCF10A. " 01/01/2020 - "Aurovertin B exerts potent antitumor activity against triple-negative breast cancer in vivo and in vitro via regulating ATP synthase activity and DUSP1 expression." 01/01/2020 - "In this study, flow cytometry and DAPI staining analysis showed that aurovertin B treatment in human triple-negative breast cancer cell MDA-MB-231 could induce more apoptotic cells than taxol treatment group. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2018 - "Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis."
5.	Breast Neoplasms (Breast Cancer) 04/01/2008 - "Aurovertin B inhibits proliferation of breast cancer cells by inducing apoptosis and arresting cell cycle at the G0/G1 phase. " 04/01/2008 - "Aurovertin B, an ATP synthase inhibitor, has strong inhibition on the proliferation of several breast cancer cell lines, but little influence on the normal cell line MCF-10A. " 04/01/2008 - "Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Paclitaxel (Taxol)
3.	Hydrolases
4.	oligomycin B
5.	DAPI
6.	Oligomycins
7.	Ligands
8.	Adenosine Triphosphatases (ATPase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Immunotherapy