|1.||Qin, Hai-Lin: 5 articles (09/2015 - 05/2012)|
|2.||Deng, An-Jun: 3 articles (09/2015 - 01/2014)|
|3.||Wang, Wen-Jie: 3 articles (09/2015 - 01/2014)|
|4.||Wu, Lian-Qiu: 3 articles (09/2015 - 01/2014)|
|5.||Zhang, Zhi-Hui: 3 articles (09/2015 - 01/2014)|
|6.||Li, Zhi-Hong: 3 articles (09/2015 - 01/2014)|
|7.||Wu, Hao: 3 articles (09/2015 - 06/2014)|
|8.||Du, Guan-Hua: 3 articles (10/2014 - 05/2012)|
|9.||Fang, Lian-Hua: 3 articles (10/2014 - 05/2012)|
|10.||Zhang, Hai-Jing: 2 articles (09/2015 - 01/2014)|
|1.||Alzheimer Disease (Alzheimer's Disease)
09/01/2015 - "The results of endotoxin neutralization assay suggest that coptisine is capable of reducing the LPS content under inflammation status. "
12/01/2013 - "Coptisine exerts pronounced cardioprotection in rats subjected to myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway."
09/01/2015 - "Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters."
09/01/2015 - "Because the fat, sterol and bile acid metabolism of male Syrian golden hamster are more similar to that of human, in the present study, high fat and high cholesterol (HFHC) induced obese hamsters were used to evaluate the anti-inflammation and hypolipidemic role of coptisine. "
12/01/2013 - "Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation."
06/01/1992 - "The present study was conducted to investigate the antinephritic effects of berberine and coptisine, which are contained in Coptidis rhizoma, on original-type anti-GBM nephritis in rats. "
06/01/1992 - "Studies on the antinephritic effect of plant components (4): Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis."
05/01/2012 - "This study aims to elucidate if coptisine is responsible for cardioprotection using myocardial infarction (MI) rat models and investigate its potential mechanism of action. "
05/01/2012 - "Coptisine provided cardioprotection in a model of myocardial infarction, and therefore should be considered as a novel adjunctive therapy for attenuating myocardial damage."
05/01/2012 - "Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats."
10/30/2014 - "Introduction of the alkyl groups into the C-13 position of quaternary coptisine (1) led to significant increase of the cytotoxic activity, while the substitution of arylmethyl groups and others at the same position showed no effect on improving cytotoxicities against the same cancer cell-lines. "
10/30/2014 - "Twenty five 13-substituted quaternary coptisine derivatives were synthesized to test their cytotoxicities against several cancer cell-lines and on intestinal epithelial cell-6 (IEC-6) in vitro to evaluate structure-activity relationship (SAR). "
01/01/2014 - "However, whether coptisine exerts anti-cancer metastasis effects remains unknown. "
05/02/2014 - "Coptisine induced cell cycle arrest at the G0/G1 phase through downregulation of CDK4 and cyclin D1 expression and effectively suppressed tumor growth in a xenografted mouse model. "
|3.||antiglomerular basement membrane antibody
|8.||Tissue Inhibitor of Metalloproteinase-1