N(2)- (gamma- D- glutamyl)- meso- 2,2'- diaminopimelic acid

intermediate in synthesis of FK-156 which is an immunostimulant; structure given in first source; RN given refers to (D)-isomer

Also Known As:

GGMDA; Heptanedioic acid, 2-amino-6-((4-amino-4-carboxy-1-oxobutyl)amino)-, (2R-(2R*,6S*(R*)))-; N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid, (L)-isomer; gamma-D-glutamyl-meso-diaminopimelic acid; iE-DAP; D-Lysine, 6-carboxy-N6-D-gamma-glutamyl-, erythro-

Networked: 20 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shen, Xiangzhen: 8 articles (02/2021 - 08/2018)
2.	Wang, Yan: 7 articles (02/2021 - 08/2018)
3.	Roy, Animesh Chandra: 6 articles (02/2021 - 03/2019)
4.	Chang, Guangjun: 5 articles (02/2021 - 08/2018)
5.	Dai, Hongyu: 5 articles (02/2021 - 08/2018)
6.	Ma, Nana: 5 articles (02/2021 - 03/2019)
7.	Cheng, Xiaoye: 3 articles (02/2021 - 01/2020)
8.	Gao, Qianyun: 3 articles (02/2021 - 06/2020)
9.	Roy, Shipra: 3 articles (01/2021 - 08/2018)
10.	Liu, Jing: 2 articles (02/2021 - 11/2019)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2021 - "The goal of the present study was to investigate whether GLN protects BMEC from iE-DAP-induced inflammation, oxidative stress, and apoptosis. " 11/01/2019 - "Therefore, the aim of our study was to investigate the role of bovine hepatocytes in NOD1-mediated inflammation during iE-DAP or LPS treatment or SB pretreatment. " 02/01/2021 - "This is the first report showing that GLN protects against iE-DAP-induced inflammation and oxidative stress via the NOD1/NF-κB and ERK/Nrf2 pathways in BMEC." 01/01/2021 - "Taken together, these findings suggest that NOD1 is a key player for regulating both ATG16L1 and RIPK2-ULK1 directed autophagy during inflammation in response to iE-DAP in bovine hepatocytes." 03/06/2020 - "In conclusion, our data confirmed the inflammatory effect of IFN-γ and iE-DAP/MDP on human FLS for the first time and therefore provided a new insight into the IFN-γ combined with NOD1 or NOD2 activated immunopathological mechanisms mediated by distinct intracellular signal transduction in joint inflammation of RA."
2.	Infections 11/01/2017 - "In this study, we use miiuy croaker (Miichthys miiuy) as a model to determine NOD1 can response to the infection of Gram-negative bacteria and it is the receptor that can recognize of iE-DAP by LRRs domain, it can activate the NF-κB signaling pathway through recruit RIP2 to induce inflammatory response in teleost fishes. " 10/01/2013 - "NOD1 expression elicited by iE-DAP in first trimester human trophoblast cells and its potential role in infection-associated inflammation." 05/03/2023 - "In the murine model of TB infection, we demonstrate that depletion of MurT-GatD in BCG, resulting in unmasking of the D-glutamate diaminopimelate (iE-DAP) NOD-1 ligand, yields superior prevention of TB disease compared to the standard BCG vaccine. "
3.	Acidosis 02/01/2021 - "Collectively, the SB supplementation mitigated the inflammatory response in the mammary glands of dairy goats during HC-induced subacute ruminal acidosis (SARA) by inhibiting the activation of the NOD1/NF-κB signaling pathway through the decrease of the iE-DAP concentration in the rumen fluid and plasma and HDAC3 expression. " 01/01/2020 - "(4) Conclusions: A HC diet fed to dairy cows incites subacute ruminal acidosis (SARA), which increases the iE-DAP concentration and induces apoptosis in the mammary gland via the NOD1/Caspase-8 pathway." 08/29/2018 - "The aim of this study is to explore the impact of sodium butyrate on d-glutamyl- meso-diaminopimelic acid (iE-DAP)-induced liver inflammation in dairy goats during subacute ruminal acidosis (SARA) caused by high-concentrate feed. "
4.	Hepatocellular Carcinoma (Hepatoma) 04/01/2016 - "In this study, we identified genes encoding components of the NOD1 signaling pathway, including NOD1 (OmNOD1) and RIP2 (OmRIP2) from rainbow trout, Oncorhynchus mykiss, and investigated whether OmNOD1 has immunomodulating activity in a rainbow trout hepatoma cell line RTH-149 treated with NOD1-specific ligand (iE-DAP). " 03/01/2023 - "Human hepatoma cells (HepG2) were exposed to conditioned medium obtained from 3 T3-L1 adipocytes pretreated with NOD1 ligand (iE-DAP) and the effects on lipid accumulation, inflammation and insulin response were assessed. "
5.	Fetal Weight 07/15/2011 - "iE-DAP at a lower dose that did not induce prematurity, reduced fetal weight, altered the cytokine profile at the maternal-fetal interface, and induced fetal inflammation. "

Related Drugs and Biologics

1.	Diaminopimelic Acid
2.	Ligands
3.	Butyric Acid (Butanoic Acid)
4.	Interleukin-8 (Interleukin 8)
5.	Cytokines
6.	Messenger RNA (mRNA)
7.	Caspase 8 (Caspase-8)
8.	Glutamic Acid (Glutamate)
9.	Conditioned Culture Media
10.	Interleukin-6 (Interleukin 6)