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viprostol
structure given in first source; RN given refers to (5Z,11alpha,13E)-isomer
Also Known As:
15-(deoxy)-16-hydroxy-16-vinylprostaglandin E2 methyl ester; 15-deoxy-16-hydroxy-16-vinyl-PGE2 methyl ester; CL 115,347; CL 115347; DHV-PGE2Me; viprostol, (+-)-isomer
Networked:
8
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins E: 2673
Dinoprostone: 10047
viprostol: 8
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins E: 2673
Dinoprostone: 10047
viprostol: 8
Related Diseases
1.
Hypertension (High Blood Pressure)
09/01/1983 - "
The present findings suggest that CL 115,347 may be useful for the treatment of human hypertension.
"
09/01/1983 - "
CL 115,347 [dl-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl prostaglandin E2 methyl ester] has a broad spectrum of antihypertensive activity in many animal hypertension models in every species tested.
"
2.
Ischemia
11/01/1989 - "
The present study evaluated the ability of DHV-PGE2ME, a topically effective 16-vinyl prostaglandin E2 analogue, to improve the tolerance of skin flaps to a period of ischemia.
"
3.
Essential Hypertension
06/01/1986 - "
The cardiovascular responses to the chronic administration of CL 115347 were studied in a double-blind, placebo-controlled trial in 26 subjects with essential hypertension (16 given drug, 10 placebo) maintained on a 100-mEq sodium diet.
"
4.
Tachycardia (Tachyarrhythmias)
02/01/1983 - "
CL 115,347 decreased vasopressor responses induced by electrical stimulation of the spinal cord at T7-T9 but did not decrease the tachycardia induced by stimulation of the cardioaccelerator segments (C7-T1) in pithed SHR.
"
12/01/1986 - "
Viprostol did not antagonize the tachycardia induced by stimulation of the discrete segments at C7-T1 (cardio-accelerator) of the spinal cord in pithed SHR, suggesting that viprostol did not activate the presynaptic alpha-adrenoceptors.
"
5.
Ganglion Cysts (Ganglion)
12/01/1986 - "
In cats, viprostol did not inhibit renal sympathetic nerve discharge (RSND) monitored at the postganglionic region, indicating that nerve transmission or conduction was not blocked at the ganglion or the pre- or postganglionic fibres.
"
Related Drugs and Biologics
1.
Dinoprostone (PGE2)
2.
Sodium
3.
Antihypertensive Agents (Antihypertensives)
4.
prostaglandin E2 methyl ester
5.
Dinoprost
6.
Adrenergic Receptors (Adrenergic Receptor)
7.
Norepinephrine (Noradrenaline)
8.
Epinephrine (Adrenaline)
9.
Catecholamines