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carbocyclic 3-deazaadenosine
carboxylic analog of 3-deazaadenosine
Also Known As:
3-deaza-C-ado; 1,2-Cyclopentanediol, 3-(4-amino-1H-imidazo(4,5-c)pyridin-1-yl)-5-(hydroxymethyl)-, (1alpha,2alpha,3beta,5beta)-(+-)-
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Tubercidin: 42
carbocyclic 3-deazaadenosine: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Tubercidin: 42
carbocyclic 3-deazaadenosine: 4
Ribonucleosides: 49
Tubercidin: 42
carbocyclic 3-deazaadenosine: 4
Related Diseases
1.
Paramyxoviridae Infections (Parainfluenza)
10/01/1990 - "
Evaluation of the toxicity and antiviral activity of carbocyclic 3-deazaadenosine against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats.
"
10/01/1990 - "
The toxicity and antiviral efficacy of carbocyclic 3-deazaadenosine (Cc3Ado) against respiratory syncytial (RSV) and parainfluenza type 3 (PIV3) virus infections were tested in tissue culture and in cotton rats.
"
2.
Virus Diseases (Viral Diseases)
10/01/1990 - "
The toxicity and antiviral efficacy of carbocyclic 3-deazaadenosine (Cc3Ado) against respiratory syncytial (RSV) and parainfluenza type 3 (PIV3) virus infections were tested in tissue culture and in cotton rats.
"
3.
Vesicular Stomatitis
05/31/1985 - "
For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hydrolase activity: (S)-9-(2,3-dihydroxypropyl)adenine less than (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) less than carbocyclic 3-deazaadenosine less than neplanocin A.
"
06/01/1989 - "
(S)-9-(2,3-dihydroxypropyl)adenine, (RS)-3-adenin-9-yl-2-hydroxypropanoic acid, carbocyclic 3-deazaadenosine and neplanocin A, which have been previously recognized as specific inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, gained a marked increase in their cytostatic activity (against tumor cells) and antiviral activity (against vaccinia and vesicular stomatitis virus) in the presence of L-homocysteine (10(-3) M).
"
4.
Ebola Hemorrhagic Fever
02/01/1999 - "
As reported here, Carbocyclic 3-deazaadenosine is the first compound demonstrated to cure animals from this otherwise lethal Ebola virus infection.
"
5.
Vaccinia
06/01/1989 - "
(S)-9-(2,3-dihydroxypropyl)adenine, (RS)-3-adenin-9-yl-2-hydroxypropanoic acid, carbocyclic 3-deazaadenosine and neplanocin A, which have been previously recognized as specific inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, gained a marked increase in their cytostatic activity (against tumor cells) and antiviral activity (against vaccinia and vesicular stomatitis virus) in the presence of L-homocysteine (10(-3) M).
"
Related Drugs and Biologics
1.
Antiviral Agents (Antivirals)
2.
Acids
3.
neplanocin A
4.
9-(2,3-dihydroxypropyl)adenine
5.
Cytostatic Agents
6.
Adenosylhomocysteinase
7.
S-Adenosylhomocysteine
8.
Hydrolases
9.
Homocysteine
10.
Esters