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2- phenylpyrazolo(4,3- c)quinolin- 3(5H)- one

a mixed agonist/antagonist of the benzodiazepine receptor
Also Known As:
CGS 8216; CGS-8216; 3H-Pyrazolo(4,3-c)quinolin-3-one, 2,5-dihydro-2-phenyl-
Networked: 31 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1. Seizures (Seizure)
2. Muscle Spasticity (Spastic)
07/17/1985 - "Effects of methyl beta-carboline-3-carboxylate, Ro 15-1788 and CGS 8216 on muscle tone in genetically spastic rats."
07/17/1985 - "beta-CCM, 2.5 and 3.0 mg/kg i.p., augmented the tonic activity in the EMG of GS muscle in spastic rats while it did not modify muscle tone at doses of 1.0 and 2.0 mg/kg. Diazepam, 0.4 mg/kg i.p., and Ro 15-1788, 5 mg/kg i.p., but not CGS 8216, 5 mg/kg i.p., antagonised the effect of the beta-carboline on muscle tone. "
07/17/1985 - "Genetically spastic rats were used for studying the effect on muscle tone of beta-carboline-3-carboxylic acid methylester (beta-CCM), an inverse benzodiazepine (BDZ) agonist, and that of Ro 15-1788 and CGS 8216, both putative antagonists of pharmacological actions of BDZs. "
10/01/1984 - "CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats."
08/22/1986 - "Beta-Carboline-3-carboxylic acid methylester (beta-CCM), 2 mg/kg i.p., while not affecting the tonic activity in the EMG, reversed the depressant effect of phenobarbitone, 30 mg/kg. Both Ro 15-1788, 5 mg/kg, and CGS 8216, 5 mg/kg, prevented the reversal of the depressant action of phenobarbitone, 30 mg/kg, produced by beta-CCM, 2 mg/kg. The results indicate that the muscle relaxant action of phenobarbitone in genetically spastic rats is mediated via GABA-related mechanisms and add further support to the hypothesis that both Ro 15-1788 and CGS 8216 are specific antagonists at benzodiazepine receptors, devoid of intrinsic activity at moderate doses. "
3. Tremor (Tremors)
4. Shock
5. Hepatic Encephalopathy

Related Drugs and Biologics

1. Flumazenil (Romazicon)
2. PK 11195 (PK11195)
3. Benzodiazepines
4. Diazepam (Valium)
5. GABA-A Receptors (GABA(A) Receptor)
6. Flurazepam (Dalmane)
7. Pentylenetetrazole (Metrazol)
8. methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate
9. beta-carboline-3-carboxylic acid methyl ester
10. FG 7142

Related Therapies and Procedures

1. Surgical Portacaval Shunt (Portacaval Anastomosis)
2. Ligation
3. Induced Hypothermia