|1.||Bussink, Johan: 25 articles (09/2014 - 09/2002)|
|2.||van der Kogel, Albert J: 24 articles (09/2014 - 09/2002)|
|3.||Rofstad, Einar K: 20 articles (10/2015 - 02/2002)|
|4.||Kaanders, Johannes H A M: 20 articles (09/2014 - 09/2002)|
|5.||Raleigh, James A: 19 articles (01/2015 - 03/2002)|
|6.||Raleigh, J A: 19 articles (03/2006 - 01/2000)|
|7.||Ling, C Clifton: 16 articles (10/2015 - 04/2005)|
|8.||Galappathi, Kanthi: 13 articles (01/2015 - 02/2002)|
|9.||Li, Xiao-Feng: 12 articles (10/2015 - 01/2007)|
|10.||Mathiesen, Berit: 11 articles (02/2014 - 02/2002)|
10/24/2014 - "In contrast to wild-type hearts that exhibited an elaborate ventricular vascular network, Tbx5(epi-/-) hearts displayed a marked decrease in vascular density that was associated with myocardial hypoxia as exemplified by hypoxia inducible factor-1α upregulation and increased binding of hypoxyprobe-1. "
12/01/2008 - "Tubular hypoxia was significantly greater in diabetic rats, indicated by a 2.5-fold increase in the proportional area of pimonidazole immunostaining (P < 0.001). "
12/01/2010 - "The results obtained by the optical technique were verified by immunohistochemical study of tissue samples marked with exogenous marker of hypoxia--pimonidazole."
11/01/2007 - "Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride."
10/01/2007 - "Immunohistochemical studies with the nitroimidazole hypoxia marker, pimonidazole, were carried out in livers from young and old rats. "
02/01/2006 - "Tumor oxygenation, as measured by the fraction of pO2 measurement <10 mmHg and the intensity of pimonidazole staining, was significantly improved in the high-dose group (P = 0.046 and 0.03, respectively, compared with controls) but not in the low-dose group. "
12/15/2006 - "This effect was also associated with improved tumor oxygenation as assessed by pimonidazole staining, decreased HIF-1alpha protein levels, and microtubule destabilization as assessed by deacetylation. "
04/01/2015 - "In ex vivo studies, in fasted mice, there was spatial colocalization between high levels of (18)F-FDG uptake and pimonidazole-binding hypoxic cancer cells; in contrast, pimonidazole-negative normoxic cancer cells and noncancerous stroma were associated with low (18)F-FDG uptake. "
06/01/2008 - "In this study, EF5 and pimonidazole binding kinetics were compared as a function of pO(2) and antibody concentration in cells of two rat (9L and R3230) and two human (HT1080 and SiHa) cancer cell lines. "
01/01/1992 - "Blood flow reductions of 30-40% were also observed in both tumors following administration of the radiation sensitiser pimonidazole (Ro-03-8799) at a dose of 500 mg/kg. Moreover studies in the C3H mammary tumor indicated that this effect was tumor size-dependent, being more profound and of longer duration in 500 mg than in 100 mg tumors. "
05/01/2013 - "Then we showed a significant reduction in pimonidazole binding in the infarcted hemisphere, when rats with 60 minutes of MCAO, immediately after establishment of cerebral reflow, had 3×15 minutes intermittent hind limb ischemia followed by 24-hour survival. "
05/01/2013 - "First, we demonstrated that a linear relationship exist between pimonidazole binding in the ischemic hemisphere and duration of ischemia, in animals subjected to 5, 15, 30, or 60 minutes of occlusion followed by 120 minutes of reflow. "
05/01/2014 - "However, localized tissue hypoxia, as evidence by pimonidazole adduct immunohistochemistry, was detected in kidneys subjected to ischemia and reperfusion, particularly in, but not exclusive to, the outer medulla. "
10/01/2009 - "Pimonidazole hydrochloride was used to assess retinal ischemia. "
08/01/2005 - "Ischemia was detected by an increase in pimonidazole adducts, as well as an increase in glucose transporter-1 protein expression. "
09/01/2013 - "Moreover, renal hypoxia (evaluated as pimonidazole adducts) was improved in the HFS + IR group compared to the HFS group in spite of anemia. "
04/01/2013 - "Heart, brain, kidneys, liver, small intestine, and skeletal muscle experience tissue hypoxia at different degrees of acute anemia, as assessed by the pimonidazole method and vascular endothelial growth factor expression. "
01/01/2013 - "These factors, combined with significant anemia found in eNOS KO fetuses, would be anticipated to reduce fetal oxygen delivery and contribute to the fetal tissue hypoxia that was detected in the heart, lung, kidney, and liver by immunohistochemistry using pimonidazole. "
08/01/2006 - "The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study."
03/10/2003 - "Pimonidazole was administered to 42 patients with advanced carcinoma of the cervix, 16 hr before biopsy. "
09/05/2001 - "Hypoxic regions of human carcinomas were chemically marked with pimonidazole. "
11/01/1998 - "Ten patients with cervical carcinoma received 0.5 g/m2 pimonidazole intravenously followed by biopsy of the cervical carcinoma the next day. "
08/01/1983 - "The nitroimidazole Ro 03-8799 has been tested as a sensitizer of hypoxic tumour cells, using regrowth delay of a mouse mammary carcinoma. "
|1.||Biological Markers (Surrogate Marker)
|6.||Carbonic Anhydrases (Carbonic Anhydrase)
|9.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|1.||Heterologous Transplantation (Xenotransplantation)