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lys-plasmin
plasmin residues (77-790)
Also Known As:
Lys(77)-plasmin; lys plasmin; plasmin (77-790)
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Peptide Hydrolases: 23957
Serine Proteases: 3726
Serine Endopeptidases: 11
Fibrinolysin: 2440
lys-plasmin: 2
Endopeptidases: 633
Serine Endopeptidases: 11
Fibrinolysin: 2440
lys-plasmin: 2
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Peptide Fragments: 373
lys-plasmin: 2
Related Diseases
1.
Venous Thrombosis (Deep-Vein Thrombosis)
06/28/1982 - "
A derivative of human lys-plasmin in which the active site has been reversibly acylated (BRL 26920; p-anisoyl human lys-plasmin) has been examined as a fibrinolytic agent in a previously described rabbit model of venous thrombosis and shown to be significantly more active and less fibrinogenolytic than free plasmin.
"
2.
Autolysis
10/25/1983 - "
This augmentation was not merely due to inhibition of Lys-plasmin autolysis since Fragment D has a greater effect in that regard.
"
10/25/1983 - "
The K4 kringle region may be particularly involved in the plasmin-plasmin interaction that results in autolysis, since it significantly reduced degradation when incubated with Lys-plasmin.
"
10/25/1983 - "
In contrast to Glu-plasminogen activation, the urokinase activation of Lys-plasminogen was not affected by fibrinogen or its fragments, yet a marked inhibition of Lys-plasmin autolysis occurred in their presence, with the half-life of plasmin being increased 13-fold by fibrinogen, 5-fold by Fragment D, and 3-fold by Fragment E.
"
Related Drugs and Biologics
1.
Fibrinolysin
2.
Urokinase-Type Plasminogen Activator (Urokinase)
3.
Plasminogen
4.
Fibrinolytic Agents (Antithrombotic Agents)
5.
Fibrinogen (Factor I)
6.
4-anisoyl activator-free plasmin
7.
lysyl-plasminogen