|1.||Mazars, Christian: 1 article (06/2009)|
|2.||Ranjeva, Raoul: 1 article (06/2009)|
|3.||Zeniou, Maria: 1 article (06/2009)|
|4.||Haiech, Jacques: 1 article (06/2009)|
|5.||Dagher, Rania: 1 article (06/2009)|
|6.||Brière, Christian: 1 article (06/2009)|
|7.||Kilhoffer, Marie-Claude: 1 article (06/2009)|
|8.||Fève, Marie: 1 article (06/2009)|
|9.||Pigault, Claire: 1 article (06/2009)|
|10.||Chneiweiss, Hervé: 1 article (06/2009)|
|1.||Breast Neoplasms (Breast Cancer)
10/01/1992 - "Pimozide, thioridazine and W-13 all exerted different effects on the distribution of human breast cancer cells within the cell cycle, suggesting that each drug may utilize a distinct pathway for inhibition of cell growth. "
01/01/1983 - "Inhibition of human breast cancer colony formation by anticalmodulin agents: trifluoperazine, W-7, and W-13."
06/15/1994 - "We compared the ability of N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide (W-13), a calmodulin antagonist, to inhibit the growth of seven human breast cancer cell lines in tissue culture, to determine whether drug sensitivity was related to estrogen receptor (ER) status, tamoxifen resistance (tamr), or levels of calmodulin activity. "
09/01/1990 - "In the present work, pimozide, thioridazine, W-13, and W-12 were shown to inhibit MCF-7 human breast cancer cell growth. "
10/01/1992 - "The sensitivity of the tamoxifen-sensitive (MCF-7) and tamoxifen-resistant human breast cancer cell growth to two noncytotoxic neuroleptic drugs, pimozide and thioridazine, and the anticalmodulin agent, W-13, were compared. "
|2.||Wilms Tumor (Wilm's Tumor)
09/01/1996 - "W13 cells, a cell line derived from a blastemal Wilms' tumor, were exposed to RA (10(-9)-10(-5) M) and its effects on cell proliferation, gene expression, and differentiation were examined. "
05/15/1996 - "Suramin was found to affect the Wilms' tumor (WT) cell line, W13, by inhibiting in vitro growth (half-maximal inhibitory dose (ID50)=11 microM), insulin like growth factor II (IGF-II) cell binding (ID50 = 10 microM) and IGF-II induced DNA synthesis (ID50 = 8 microM). "
05/15/1996 - "When administered to athymic mice bearing W13 heterotransplants, suramin suppressed the linear tumor growth rate by 64%."
06/01/2009 - "In the present paper, the effect of six classical CaM interactors (W5, W7, W12, W13, bifonazole and calmidazolium) was studied on Ca2+-signalling in tumor initiating cells isolated from human glioblastoma (TG1) and tobacco cells (BY-2) using the fluorescent Ca2+-sensitive Indo-1 dye and aequorin, respectively. "
|5.||Hyperaldosteronism (Conn Syndrome)
02/01/1997 - "The calmodulin antagonist W-13 (60 mmol/L) decreased exchanger velocity and increased Km for both H+ and Na+. We conclude that aldosterone stimulates red blood cell Na(+)-H+ exchange by a nongenomic mechanism that augments the exchanger affinity to Na+ and H+. In primary aldosteronism, protein kinase C and calmodulin seem to have synergistic stimulatory effects on red blood cell Na(+)-H+ exchange, and both increase the affinity of the exchanger to H+, while their effect on Na+ binding is opposite."
|1.||Calmodulin (Calcium-Dependent Activator Protein)
|3.||W 7 (W7)
|8.||1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)
|9.||Antipsychotic Agents (Antipsychotics)
|10.||Suramin (Suramin Sodium)