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4-carbamoylimidazolium 5-olate
purine antagonist; RN given refers to parent cpd
Also Known As:
4-carbamoylimidazolium 5-olate, sodium salt; 5-hydroxyimidazole 4-carboxamide; SM 108; SM-108
Networked:
13
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
4-carbamoylimidazolium 5-olate: 13
Related Diseases
1.
Polycythemia Vera
01/01/1989 - "
Mean dosages of SM-108 until remission were 400-500 mg/m2/day on CMMoL, RAEB in MDS, polycythemia vera and CML, and 600-800 mg/m2/day on RAEB in T and AML.
"
01/01/1989 - "
Our study indicates that SM-108 is useful agent against MDS, especially CMMoL, RAEB, RAEB in T, polycythemia vera and CML.
"
2.
Refractory Anemia with Excess of Blasts (RAEM)
01/01/1989 - "
Mean dosages of SM-108 until remission were 400-500 mg/m2/day on CMMoL, RAEB in MDS, polycythemia vera and CML, and 600-800 mg/m2/day on RAEB in T and AML.
"
01/01/1989 - "
Our study indicates that SM-108 is useful agent against MDS, especially CMMoL, RAEB, RAEB in T, polycythemia vera and CML.
"
3.
Hematologic Neoplasms (Hematological Malignancy)
01/01/1989 - "
[Phase II study of SM-108 (4-carbamoylimidazolium-5-olate) in hematological malignancies].
"
4.
Lung Neoplasms (Lung Cancer)
01/01/1989 - "
[Phase I study and early phase II of SM-108 (4-carbamoylimidazolium-5-olate) in lung cancer.
"
5.
Carcinoma (Carcinomatosis)
10/01/1985 - "
The antitumor activity of SM-108 against Ehrlich carcinoma was so remarkable, in fact, that all mice in a group survived for a long time.
"
12/01/1983 - "
Among them, Ehrlich carcinoma showed the most prominent susceptibility to SM-108.
"
12/01/1983 - "
Although usual daily administration of SM-108 exhibited poor efficacy, the intermittent multiple administration of SM-108 exhibited potent antitumor activity against a wide variety of tumors, such as Ehrlich carcinoma, P388, 6-mercaptopurine-sensitive and -resistant L1210, Lewis lung carcinoma, Colon 26 adenocarcinoma, and Sarcoma 180.
"
01/01/1986 - "
Ehrlich carcinoma and P388 leukemia cells were rendered resistant to 4-carbamoylimidazolium 5-olate (SM-108), and assessments were made of biochemical and pharmacological determinants for the sensitivity to SM-108 using both sensitive and resistant sublines.
"
10/01/1982 - "
4-Carbamoylimidazolium 5-olate (CIO), the aglycone of the nucleoside antibiotic, bredinin (4-carbamoyl-1-beta-D-ribofuranosylimidazolium 5-olate), exhibited potent cytotoxic effects of subclonal line F28-7 of C3H mouse mammary carcinoma FM3A cells in culture.
"
Related Drugs and Biologics
1.
IMP Dehydrogenase
2.
4-carbamoylimidazolium 5-olate
3.
purine
4.
Magnesium Chloride
5.
Mercaptopurine (6 Mercaptopurine)
6.
Ribavirin (Virazole)
7.
Oxidoreductases (Dehydrogenase)
8.
Nucleosides
9.
Inosine
10.
Guanosine
Related Therapies and Procedures
1.
Remission Induction