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1,4- dihydro- 2,6- dimethyl- 4- (3- nitrophenyl)- 3,5- pyridinedicarboxylic acid dimethyl ester

structure given in first source

Also Known As:

2,6-dimethyl-3,5-dicarbomethoxy-4-(3-nitrophenyl)-1,4-dihydropyridine; 3-nifedipine; Bay A4339; m-nifedipine

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - Nifedipine: 5733
        1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester: 14

Experts

1.	Flynn, J C: 1 article (08/2006)
2.	Henderson, J S: 1 article (08/2006)
3.	Johnson, R B: 1 article (08/2006)
4.	Himmel, H M: 1 article (08/2001)
5.	Ravens, U: 1 article (08/2001)
6.	Stengel, W: 1 article (08/2001)

Related Diseases

1.	Ischemia 01/01/1993 - "The protective effects of m-nifedipine (m-Nif) and nifedipine (Nif) were studied in isolated rat hearts subjected global ischemia and reperfusion. " 09/01/1999 - "Accordingly, the functional and metabolic influence of four different Ca2+-antagonists (diltiazem, 3x10(-8) M; nifedipine, 3x10(-9) M; amlodipine, 3x 10(-9) M; barnidipine, 3x10(-11) M) was examined in preparations of guinea pig hearts (n=7/group) performing pressure-volume work after being subjected to low-flow ischemia (30 min) and reperfusion (35 min). "
2.	Hypertrophy 01/01/1996 - "The effects of m-nifedipine (m-Nif) and nifedipine (Nif) on prevention of hypertrophy and the possible mechanism were investigated. " 01/01/1995 - "The hemodynamic changes of metoprolol (Met, 50 mg.kg-1.d-1, po, 3 wk) withdrawal for 1 day and the effects of nifedipine (Nif) and m-nifedipine (m-Nif) on these changes were observed in pressure overload hypertrophy in rats by abdominal aortic constriction for 4 wk. Both Nif and m-Nif (10 mg.kg-1.d-1, respectively, po, 3 wk) significantly attenuated the increase of MAP (from 14.3 +/- 2.3 to 12.9 +/- 2.3 and 11.3 +/- 2.4 kPa, respectively, n = 6-7, P < 0.05) and decrease the abnormal development of systolic function of left ventricle after Met withdrawal. "
3.	Stroke (Strokes) 01/01/1992 - "Three groups of adult stroke--prone spontaneously hypertensive rats (SHRsp) were treated with m-nifedipine (m-Nif) 2.5, 5 and 10 mg.kg-1 by intraperitoneal injection. "
4.	Gingival Overgrowth 08/01/2006 - "In addition, the exposure of fibroblasts derived from gingival overgrowth to either 400 ng/ml cyclosporine A + 10(-7) m nifedipine or 400 ng/ml cyclosporine A + 10(-10) m nifedipine significantly increased or decreased, respectively, the incorporation of [(35)S]sulfate into the cultures. "
5.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/01/1995 - "Effects of m-nifedipine (m-Nif) on the affinity and density of dihydropyridine (DHP) binding sites in the cell membranes of kidney and lung were investigated using the LVH (left ventricular hypertrophy) induced by Goldblatt (2k-1c) renovascular hypertension in elderly rats. "

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	1,4-dihydropyridine (dihydropyridine)
3.	Amlodipine (Norvasc)
4.	Cyclosporine (Ciclosporin)
5.	Sulfates (Sulfates, Inorganic)
6.	Metoprolol (Toprol-XL)
7.	Diltiazem (Cardizem)
8.	Cations
9.	Calcium
10.	1,4- dihydro- 2,6- dimethyl- - 4- (3- nitrophenyl)- 3,5- pyridinedicarboxylic acid ethyl-1-methylethyl ester

Related Therapies and Procedures

1.	Intraperitoneal Injections