puerarin

09/12/2023 - "More and more evidence suggests that puerarin, a potential remedy for gut inflammation, may have an ameliorative effect on sleep disturbances. "
05/01/2019 - "Puerarin showed cardio-protective effects on DCM by inhibiting inflammation, and it might be a potential candidate for the treatment of DCM."
01/01/2018 - "The results in this study indicated that puerarin ameliorates AD-like skin lesion and skin inflammation via regulation of various atopic and inflammatory mediators. "
12/01/2020 - "Puerarin increased the BMD and improved the intestinal mucosal integrity to reduce the systemic inflammation. "
07/15/2022 - "Recent studies have suggested that ferroptosis may involve puerarin countering inflammation. "

12/01/2019 - "In our current study, we attempted to explore the protective effects of puerarin against hypoxia-caused damages in neural stem cells (NSCs). "
12/01/2019 - "Puerarin has been reported to be useful in protection against hypoxia-induced injury. "
06/01/2014 - "Thus, for the first time, we revealed the protective effects of puerarin in cardiomocytes from anoxia/reoxygenation injury are mediated by PKCε."
06/01/2014 - "The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε."
09/01/2022 - "In the present study, we evaluated the efficacy of puerarin in the treatment of experimental PH. PH was induced in rats by a single injection of MCT (50 mg/kg, sc), and in mice by exposure to hypoxia (10% O2) for 14 days. "

01/01/2017 - "Our study suggests that puerarin could confer a neuroprotection against cerebral ischemia, and this biological function is associated with attenuating autophagy in neurons but not in astrocytes."
12/05/2013 - "This study was to investigate whether activating the cholinergic anti-inflammatory pathway can be involved in the mechanism of inhibiting the inflammatory response during puerarin-induced cerebral ischemia/reperfusion in rats. "
02/23/2005 - "Another novel finding of this study was that the elimination rate of puerarin was significantly slower in the cerebral ischemia reperfusion rat than in the normal rat, judging by the pharmacokinetic parameters obtained. "
02/05/2019 - "Puerarin, isolated from the roots of Pueraria lobata, is widely used for treating cerebral ischemia in China. "
02/05/2019 - "Distribution kinetics of puerarin in rat hippocampus after acute local cerebral ischemia."

10/01/2018 - "At 24 weeks, insulin resistance was indicated with more pronounced improvement in the puerarin group versus the control group (homeostasis model assessment, -0.40; 95% CI, -0.47 to -0.33vs -0.05; 95% CI, -0.08 to -0.01; P < 0.001). "
10/01/2020 - "Therefore, puerarin can decrease the expression of TNF-α and ameliorate insulin resistance in GDM rats, suggesting the potential efficacy of puerarin in GDM treatment."
10/01/2018 - "In the study, 24 weeks of treatment with 400mg of puerarin exerted a significant effect against CIMT progression in patients with active RA, which may be associated with the improvement of insulin resistance. "
10/01/2018 - "Correlation analysis indicated an interaction between the parallel reductions in CIMT and insulin resistance in the puerarin group (r = 0.878, P < 0.001) but not in the control group. "
01/05/2018 - "However, the target tissues and underlying mechanisms in and through which puerarin functions to ameliorating insulin resistance remains largely unclear. "

03/24/2016 - "Puerarin has protective effects on ischemia-reperfusion injury, but the underlying mechanisms are not fully revealed. "
01/01/2015 - "This study was designed to explore the mechanism of puerarin in treatment of acute spinal ischemia-reperfusion injury in rats. "
06/01/1992 - "To ascertain the beneficial effect of puerarin on the myocardium against reperfusion injury, studies on myocardial metabolism and ultrastructure were made. "
01/01/2022 - "With the deepening of experimental research and clinical research on puerarin, it has been found that puerarin has a protective effect on ischemia-reperfusion injury (IRI) of the heart, brain, spinal cord, lung, intestine and other organs. "
06/01/2018 - "Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway."