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CRM45 fragment of diphtheria toxin

45,000-dalton protein of mutated tox gene from diphtheria toxin

Also Known As:

CRM 45; CRM-45; CRM45; cross reacting material (CRM(45)) of diphtheria toxin; cross reacting material 45

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Bacterial Proteins: 394
    - CRM45 fragment of diphtheria toxin: 5

Experts

1.	Disanzo, Beth L: 1 article (10/2011)
2.	Gong, Dawei: 1 article (10/2011)
3.	Wang, Xuewen: 1 article (10/2011)
4.	Yang, Rongze: 1 article (10/2011)
5.	You, Tongjian: 1 article (10/2011)

Related Diseases

1.	Overweight 10/28/2011 - "Thirty overweight or obese, middle-aged women (BMI = 34.3 ± 0.8 kg/m2, age = 59 ± 1 years) underwent one of three 20-week weight loss interventions: caloric restriction only (CR, N = 9), caloric restriction plus moderate-intensity aerobic exercise (CRM, 45-50% HRR, N = 13), or caloric restriction plus vigorous-intensity aerobic exercise (CRV, 70-75% HRR, N = 8). "
2.	Weight Loss (Weight Reduction) 10/28/2011 - "Thirty overweight or obese, middle-aged women (BMI = 34.3 ± 0.8 kg/m2, age = 59 ± 1 years) underwent one of three 20-week weight loss interventions: caloric restriction only (CR, N = 9), caloric restriction plus moderate-intensity aerobic exercise (CRM, 45-50% HRR, N = 13), or caloric restriction plus vigorous-intensity aerobic exercise (CRV, 70-75% HRR, N = 8). "
3.	Pituitary Diseases (Disease, Anterior Pituitary) 01/01/1986 - "As a preliminary step in evaluating the use of thyrotropin releasing hormone (TRH) linked to toxin fragments for systemic treatment of pituitary disease, we have examined the metabolic degradation, tissue distribution, renal excretion, and toxicity in rats of TRH-CRM45 which consists of TRH coupled to CRM45, a diphtheria toxin-related polypeptide. "
4.	Paralysis (Palsy) 01/01/1982 - "After intracerebral injection, however, small amounts of CRM45 led to paralysis and death, even in mice and rats--species that are resistant to toxin administered intravenously. "
5.	Neoplasms (Cancer) 08/01/1975 - "About the same amount of CRM45, a tox gene product serologically related to diphtheria toxin but only 1/10,000th as toxic for guinea pigs, will also cause temporary regression in tumor-bearing mice."

Related Drugs and Biologics

1.	Diphtheria Toxin
2.	Thyrotropin-Releasing Hormone (Protirelin)
3.	Peptides (Polypeptides)
4.	CRM 107 (CRM107)

Related Therapies and Procedures

1.	Caloric Restriction