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rentiapril
RN given refers to cpd without isomeric designation
Also Known As:
2-(2'-hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidine carboxylic acid; SA 446; SA-446; rentiapril, (2R-cis)-isomer
Networked:
8
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Propionates: 988
3-Mercaptopropionic Acid: 100
rentiapril: 8
Sulfur Compounds: 278
Sulfhydryl Compounds: 4168
3-Mercaptopropionic Acid: 100
rentiapril: 8
Thiazoles: 392
Thiazolidines: 105
rentiapril: 8
Related Diseases
1.
Hypertension (High Blood Pressure)
12/01/1986 - "
Spironolactone (25 mg/kg/day, p.o.) and kallidinogenase (25 KU/day, i.m.) also showed beneficial effects on glomerular histopathological changes and hypertension, although both drugs were not as effective as SA-446.
"
07/01/1989 - "
The results indicate that rentiapril is as effective as the other two drugs in patients with hypertension and that alacepril is more effective in patients with low-renin hypertension or renin-independent hypertension than captopril or rentiapril.
"
2.
Nephritis
11/01/1985 - "
[Antinephritic effect of SA-446, an angiotensin I converting enzyme inhibitor, on crescentic-type anti-GBM nephritis in rats].
"
12/01/1986 - "
The present study was made to clarify the mechanisms of the antinephritic action of SA-446, an angiotensin I converting enzyme inhibitor, on crescentic-type anti-GBM nephritis in rats as compared to the actions of spironolactone (an antialdosterone agent), kallidinogenase (a kallikrein agent) and saralasin (an angiotensin II antagonist).
"
3.
Essential Hypertension
07/01/1989 - "
The effects of captopril, rentiapril, and alacepril were compared in five patients with renovascular hypertension (RVH) and five with essential hypertension (EH).
"
06/01/1984 - "
[Effects of 3 different angiotensin converting enzyme inhibitors, MK 421, SQ 14225 and SA 446 on renal function and blood pressure in patients with essential hypertension].
"
4.
Acute Kidney Injury (Acute Renal Failure)
11/01/1982 - "
Effect of azosemide following pretreatment with SA-446, an angiotensin I converting enzyme inhibitor, or propranolol, a beta-adrenergic blocker, in HgCl2-induced acute renal failure in rats].
"
5.
Hypotension (Low Blood Pressure)
03/01/1988 - "
An i.v. administration of SA-446 at a dose of 1 mg/kg induced a considerable hypotension in both types of hypertensive rats and increased the flow rates in most organs, along with an increase of cardiac output.
"
Related Drugs and Biologics
1.
Captopril (Capoten)
2.
Renin
3.
alacepril
4.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
5.
antiglomerular basement membrane antibody
6.
Spironolactone (Aldactone)
7.
Saralasin (Saralasin Acetate)
8.
Kallikreins (Kallikrein)
9.
Angiotensin II
10.
Propranolol (Inderal)