alphadolone (alfadolone)

RN given refers to (3alpha,5alpha)-isomer

Also Known As:

alfadolone; 21-acetoxy-3-alpha-hydroxy-5-alpha-pregnane-11,20-dione; alphadolone acetate; alphadolone, (3alpha,5beta)-isomer; alphadolone, (3beta,5alpha)-isomer

Networked: 19 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnanediones
        alphadolone: 19

Experts

1.	Goodchild, C S: 1 article (04/2001)
2.	Nadeson, R: 1 article (04/2001)
3.	Robinson, A: 1 article (04/2001)

Related Diseases

1.	Critical Illness (Critically Ill) 05/01/1983 - "The safety and efficacy of prolonged infusion of alphaxalone/alphadolone (Alfathesin: Glaxo) was assessed in 20 critically ill patients needing sedation during intermittent positive pressure ventilation in a general intensive care unit. "
2.	Tachycardia (Tachyarrhythmias) 06/27/1997 - "In rats anaesthetised with alphaxalone/alphadolone, electrical stimulation (10 s trains of 1 ms pulses at 80 Hz, 40-80 microA) in the dorsolateral and lateral periaqueductal grey matter (PAG), the midbrain defence area, evoked a pressor response with tachycardia and vasodilatation in the hindlimb. " 01/03/1995 - "In rats anaesthetised with alphaxalone/alphadolone, electrical stimulation in the dorsal part of the periaqueductal grey matter (PAG) produced a pressor response with tachycardia and vasodilatation in the hind limb, a pattern known as the 'cardiovascular defence reaction' owing to its resemblance to fear-induced hemodynamic changes. " 07/18/1994 - "In rats anaesthetised with alphaxalone/alphadolone, electrical stimulation in the dorsolateral part of the periaqueductal grey matter (PAG; 10 s trains of 1 ms pulses at 80 Hz, 40-80 microA) evoked a pressor response accompanied by tachycardia. " 01/01/1992 - "In rats anaesthetised with alphaxalone/alphadolone, electrical stimulation in the dorsal periaqueductal grey matter (PAG) evoked a pressor response with tachycardia, vasodilatation in the hindlimb and hyperpnoea: a pattern of response known as the defence reaction. "
3.	Body Weight (Weight, Body) 01/01/1988 - "This report describes 75 cases of reliable 1-2-hour surgical anesthesia of newborn to adult squirrel monkeys, with rapid induction and recovery, using a single intramuscular dose of alphaxolone-alphadolone (doses between 11.5 and 30 mg/kg body weight)." 03/01/1975 - "Total rats tolerated to daily administration of 60 mg/kg of alphadolone acetate or of 20 ml/kg of 20 per cent Cremophor solution, without showing significant changes in body weight curves and food intake. " 06/01/1984 - "Seizure duration in unilateral electroconvulsive therapy (ECT) was recorded by means of EEG in an intraindividual comparison of etomidate (dissolved in a soy-bean oil emulsion) 0.3 mg/kg and Althesin (alphaxalone 9 mg and alphadolone 3 mg/ml) 0.6 mg/kg with methohexitone 1 mg/kg body weight. "
4.	Myalgia 07/01/1982 - "Minor complications included one adverse reaction to alphaxalone-alphadolone acetate (Althesin), one prolonged episode of laryngeal spasm after removal of the bronchoscope, and subsequent muscle pain attributed to suxamethonium in 36 patients. "
5.	Stupor 01/01/1983 - "Acoustic reflex can be elicited with Ketamin-hydrochlorid and Alphaxalone-alphadolone acetate narcosis. "

Related Drugs and Biologics

1.	alphaxalone (alfaxalone)
2.	Alfaxalone Alfadolone Mixture
3.	Thiopental (Pentothal)
4.	Succinylcholine (Suxamethonium Chloride)
5.	Soybean Oil
6.	Solutions
7.	Pentobarbital (Nembutal)
8.	Pentagastrin (Peptavlon)
9.	Oxygen (Dioxygen)
10.	Nitrous Oxide (Laughing Gas)

Related Therapies and Procedures

1.	Intermittent Positive-Pressure Ventilation
2.	Intravenous Administration
3.	Bronchoscopes
4.	Tracheotomy
5.	Microspheres (Microsphere)