N- cyclohexyl- 5- O- acetyl- 2,4- O- (4- methoxybenzylidene)glucaro- 1- amide- 6,3- lactone

affects colonic carcinogenesis in rats given azoxymethane; structure given in first source

Also Known As:

C-GAL; N-cyclohexyl-5-O-acetyl-2,4-O-(p-methoxybenzylidene)glucaro-1-amide-6,3-lactone; D-Glucar-1-amic acid, N-cyclohexyl-2,4-O-((4-methoxyphenyl)methylene)-, gamma-lactone, 5-acetate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        N-cyclohexyl-5-O-acetyl-2,4-O-(4-methoxybenzylidene)glucaro-1-amide-6,3-lactone: 2

Experts

1.	Chen, Jie: 1 article (01/2002)
2.	Palmieri, Michael: 1 article (01/2002)
3.	Reynolds, Robert: 1 article (01/2002)
4.	Segal, Stanton: 1 article (01/2002)
5.	Yager, Claire: 1 article (01/2002)

Related Diseases

1.	Carcinogenesis 01/01/1982 - "It is concluded that, since bacterial beta-glucuronidase activity in the feces of rats given 0.1% C-GAL was significantly inhibited, intestinal microfloral beta-glucuronidase may play an important role in colonic carcinogenesis caused by AOM."
2.	Neoplasms (Cancer) 01/01/1982 - "However, the number of tumors in the large intestine of the rats given C-GAL at the same time as AOM was significantly lower than in the control rats, especially in the proximal half of the colon, but those given C-GAL after AOM treatment had almost the same number of colon tumors as did the controls. "
3.	Galactosemias (Galactosemia) 01/01/2002 - "We prepared trimethylsilyl (TMS) derivatives and used alpha-D-[2-(13)C]Gal-1-P as the internal standard for GC/MS. Results obtained with this method were compared with those determined by the established enzymatic method for samples from 23 healthy individuals (11 children and 12 adults), 9 suspected patients with galactosemia, 12 galactosemic patients on diet therapy, and 2 newly diagnosed toxic neonates. "

Related Drugs and Biologics

1.	Glucuronidase

Related Therapies and Procedures

1.	Diet Therapy (Therapy, Diet)