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1,8-dinitropyrene

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Pyrenes: 10
        1,8-dinitropyrene: 9
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Pyrenes: 10
    - 1,8-dinitropyrene: 9

Related Diseases

1.	Neoplasms (Cancer) 08/01/1986 - "Female mice treated with 200 nmol of 1,3-, 1,6- or 1,8-dinitropyrene did not develop liver tumors but the hepatic tumor incidence in males was 20, 32 and 16%, respectively, which was significantly greater than that found in mice treated with pyrene. " 12/19/2022 - "1-Nitropyrene (1-NP) and 1,8-dinitropyrene (1,8-DNP) are diesel exhaust constituents and are classified by the International Agency for Research on Cancer as probable (Group 2A) or possible (Group 2B) human carcinogens. " 05/01/1984 - "The environmental mutagens, 1-nitropyrene, 1,3-dinitropyrene, 1,6-dinitropyrene and 1,8-dinitropyrene were evaluated for their ability to initiate skin tumors in male and female SENCAR mice. "
2.	Fibrosarcoma 04/01/1986 - "Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene." 11/01/1985 - "Activation of K-ras and oncogenes other than ras family in rat fibrosarcomas induced by 1,8-dinitropyrene." 11/01/1985 - "Oncogenes of fibrosarcomas of rats, induced by subcutaneous injection of 1,8-dinitropyrene (1,8-DNP), were examined by NIH 3T3 cell transfection assay and Southern blot analysis. " 04/01/1986 - "Restriction enzyme maps were made of the region around exons 1 and 2 of activated c-Ki-ras of a fibrosarcoma (1,8-DNP2) induced in a rat by 1,8-dinitropyrene. "
3.	Lymphoma (Lymphomas) 03/01/1982 - "The mutagenic potency of 1,8-dinitropyrene in cultured mouse lymphoma cells." 03/01/1982 - "Although non-toxic, 1,8-dinitropyrene (1,8-DNP) was mutagenic for mouse lymphoma L5178Y cell when assayed for induced resistance to 6-thioguanine, methotrexate, ouabain and 1-beta-D-arabinofuranosyl cytosine. "
4.	Leukemia 07/01/1991 - "1,8-Dinitropyrene also induced a significant incidence of leukemia. "
5.	Hepatocellular Carcinoma (Hepatoma) 10/01/1994 - "The mutagenicity, metabolism, DNA adduction and induction of unscheduled DNA synthesis (UDS) of 1-nitropyrene and 1,8-dinitropyrene were investigated in the human hepatoma cell line HepG2. "

Related Drugs and Biologics

1.	pyrene
2.	1-nitropyrene
3.	1,6-dinitropyrene
4.	Thioguanine (Tioguanine)
5.	Ouabain (G Strophanthin)
6.	Mutagens
7.	Methotrexate (Mexate)
8.	Enzymes
9.	DNA (Deoxyribonucleic Acid)
10.	Cytosine

Related Therapies and Procedures

1.	Subcutaneous Injections