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1,6-dinitropyrene
Networked:
11
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
1,6-dinitropyrene: 11
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
1,6-dinitropyrene: 11
Related Diseases
1.
Neoplasms (Cancer)
09/05/1997 - "
Direct pulmonary instillation of 1,6-dinitropyrene (DNP) into male Fischer 344 rats results in a dose-dependent induction of lung tumors and 6-thioguanine-resistant (TGr) T-lymphocytes.
"
06/01/1995 - "
1,6-Dinitropyrene (0-150 micrograms) was applied directly to the lungs of male F344 rats according to a protocol known to induce lung tumors.
"
09/05/1997 - "
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
"
10/01/1995 - "
In these experiments, 1,6-dinitropyrene was implanted into the lungs of rats according to a protocol known to induce lung tumors; the DNA adducts were characterized and quantified in target (lung) and surrogate (liver, white blood cells, and spleen lymphocytes) tissues.
"
10/01/1994 - "
These findings indicate that concentrations of 1,6-dinitropyrene that produce a dose-dependent induction of lung tumors also result in a dose-dependent formation of DNA adducts and induction of lymphocyte mutations but that the dose-response curves for DNA binding and mutations are different.
"
2.
Hepatocellular Carcinoma (Hepatoma)
11/01/1990 - "
Cell lines such as hamster V79, BHK, rat hepatoma H4IIEC3G- or fibroblast 208F, which are sensitive to 1,6-dinitropyrene (1,6-DNP), possess high transferase activities ranging from 120-270 nmol/min x mg protein.
"
3.
Fibrosarcoma
03/01/1987 - "
Active H-ras and N-ras in rat fibrosarcomas induced by 1,6-dinitropyrene.
"
03/01/1987 - "
The activated oncogenes in rat fibrosarcomas induced by subcutaneous injection of 1,6-dinitropyrene (1,6-DNP), an environmental mutagen-carcinogen, were examined by NIH3T3 cell transfection assay and Southern blot analysis.
"
4.
Chromosome Aberrations (Chromosome Abnormalities)
11/01/1982 - "
The ability of 1,6-dinitropyrene and 1,8-dinitropyrene to induce chromosome aberrations has been examined in a rat epithelial cell line (RL4).
"
5.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
04/01/1986 - "
Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene.
"
Related Drugs and Biologics
1.
DNA Adducts
2.
Mutagens
3.
1,8-dinitropyrene
4.
Transferases
5.
Proteins (Proteins, Gene)
6.
Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
7.
Environmental Pollutants (Pollutants, Environmental)
8.
DNA (Deoxyribonucleic Acid)
9.
Carcinogens
10.
1,3-dinitropyrene
Related Therapies and Procedures
1.
Subcutaneous Injections