harpagoside

glycoside of a cyclopenta[c]pyran from root of S. African plant Harpagophytum procumbens DC; structure in Negwer, 5th ed, #5281, 7th ed #9921; Harpagophytum extract WS 1531 is plant extract containing harpagoside; Antidiabetic Agent

Also Known As:

Networked: 34 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gagnier, Joel J: 3 articles (12/2014 - 09/2004)
2.	Wang, Wei: 2 articles (01/2022 - 03/2009)
3.	Bombardier, Claire: 2 articles (12/2014 - 01/2007)
4.	van Tulder, Maurits W: 2 articles (12/2014 - 01/2007)
5.	Chrubasik, S: 2 articles (06/2007 - 07/2004)
6.	Chrubasik, Sigrun: 2 articles (03/2006 - 09/2004)
7.	Gxaba, Nomagugu: 1 article (06/2022)
8.	Manganyi, Madira Coutlyne: 1 article (06/2022)
9.	Cai, Weikang: 1 article (01/2022)
10.	Cao, Jing: 1 article (01/2022)

Related Diseases

1.	Osteoarthritis 01/01/2017 - "Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes." 12/01/2003 - "In order to add data on the efficacy and long-term safety of an aqueous extract (Doloteffin; 2400 mg extract daily, corresponding to 50 mg harpagoside), which has been tested successfully in patients with low back pain, an uncontrolled multicentre drug surveillance study for about 12 weeks was conducted in 75 patients with arthrosis of the hip or knee. " 09/14/2005 - "Their root extracts contain the iridoid glycoside, harpagoside, which has been found to be effective in the treatment of degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, and heart disease. "
2.	Cognitive Dysfunction 01/01/2018 - "Overall, our study suggested that harpagoside treatment might be a potential therapeutic drug targeting the cognitive impairments of VaD." 09/10/2015 - "Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways."
3.	Inflammation (Inflammations) 09/25/2015 - "Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca(2+) Signaling Pathway and Prevents Inflammation-Mediated Bone Loss." 05/01/2012 - "Effect of silymarin and harpagoside on inflammation reaction of BEAS-2B cells, on ciliary beat frequency (CBF) of trachea explants and on mucociliary clearance (MCC)." 03/15/2009 - "Harpagoside, a major bioactive iridoid glucoside in genus Scrophularia, has been widely used in clinical practice for the treatment of pain in the joints and lower back for its neuroprotective and anti-inflammation activities. " 05/01/2008 - "Its major active components, harpagoside (1), harpagide (2), 8-coumaroylharpagide (3), and verbascoside (4), are believed to interact either synergistically or antagonistically in modulating the enzymes responsible for inducing inflammation, although this has not been probed hitherto. " 08/10/2022 - "Harpagoside (HAR), an iridoid glycoside, has various pharmacological effects on pain, arthritis, and inflammation. "
4.	Tendinopathy (Tendonitis) 09/14/2005 - "Their root extracts contain the iridoid glycoside, harpagoside, which has been found to be effective in the treatment of degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, and heart disease. "
5.	Heart Diseases (Heart Disease) 09/14/2005 - "Their root extracts contain the iridoid glycoside, harpagoside, which has been found to be effective in the treatment of degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, and heart disease. "

Related Drugs and Biologics

1.	Iridoids
2.	Glycosides
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Amyloid (Amyloid Fibrils)
5.	harpagide
6.	Doloteffin
7.	rofecoxib (Vioxx)
8.	Phytochemicals
9.	Iridoid Glycosides
10.	Methazolamide

Related Therapies and Procedures

1.	Therapeutics
2.	Epidural Injections
3.	Injections