lathosterol delta-5-dehydrogenase (lathosterol oxidase)

forms 7-dehydrocholesterol (cholesta-5,7-dien-3-beta-ol)
Also Known As:
lathosterol oxidase; 3beta-hydroxysteroid-delta5-desaturase; 5 alpha-cholest-7-en-3 beta-ol delta-5-dehydrogenase; SC5D; STE1 protein, Arabidopsis; delta 5,7-sterol delta-7-reductase; delta 7-sterol 5-desaturase; delta 7-sterol desaturase; delta 7-sterol reductase; lathosterol 5-desaturase
Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Porter, Forbes D: 3 articles (07/2010 - 07/2003)
2. Wassif, Christopher A: 3 articles (07/2010 - 07/2003)
3. Yergey, Alfred L: 1 article (07/2010)
4. Backlund, Peter S: 1 article (07/2010)
5. Jiang, Xiao-Sheng: 1 article (07/2010)
6. Loh, Y Peng: 1 article (05/2006)
7. Gondré-Lewis, Marjorie C: 1 article (05/2006)
8. Parsegian, Adrian: 1 article (05/2006)
9. Petrache, Horia I: 1 article (05/2006)
10. Harries, Daniel: 1 article (05/2006)

Related Diseases

1. Smith-Lemli-Opitz Syndrome
04/01/1999 - "Future efforts should identify a postulated intracellular signalling activity of sterol intermediates, isolate proteins that govern the sterol traffic between intracellular compartments, structurally characterize the enzyme delta 7-sterol reductase defective in the Smith-Lemli-Opitz syndrome and investigate the pathomechanism of sterol depletion-induced dysmorphogenesis."
05/01/2006 - "Here, we have investigated the mechanism by which cholesterol affects secretory granule biogenesis in vivo using Dhcr7(-/-) and Sc5d(-/-) mouse models of the human diseases, Smith-Lemli-Opitz syndrome (SLOS) and lathosterolosis. "
04/01/2000 - "They impair the activity of a putative C3-sterol dehydrogenase (Nshdl, X-linked dominant bare patches/striated mutation in mice), the sterol delta 8-delta 7 isomerase/EBP (Ebp, X-linked dominant tattered mutation in mice; chondrodysplasia punctata (CDPX2) in humans), the delta 24-sterol reductase (autosomal recessive desmosterolosis) and the delta 7-sterol reductase (DHCR7 gene, autosomal recessive Smith-Lemli-Opitz syndrome in humans). "
08/01/1996 - "Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital anomalies/mental retardation disorder possibly due to a defect of delta 7-sterol reductase, leading to low plasma cholesterol levels and to the accumulation of 7-dehydrocholesterol (7-DHC) and other cholesterol precursors. "
07/01/2010 - "Smith-Lemli-Opitz syndrome (SLOS) and lathosterolosis are malformation syndromes with cognitive deficits caused by mutations of 7-dehydrocholesterol reductase (DHCR7) and lathosterol 5-desaturase (SC5D), respectively. "
2. Mental Retardation (Idiocy)
3. Cleft Palate (Palate, Cleft)
4. Chondrodysplasia Punctata (Stippled Epiphyses)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Cholesterol
2. Lathosterolosis
3. lathosterol delta-5-dehydrogenase (lathosterol oxidase)
4. Messenger RNA (mRNA)
5. Proteins (Proteins, Gene)
6. Oxidoreductases
7. delta 24-sterol reductase
8. 7-dehydrocholesterol reductase
9. 7-dehydrocholesterol
10. lathosterol