RV 538 (PDMP)

noninactivating inhibitor of ceramide-UDPG glucosyltransferase; RN given for unspecified HCl; structure given in first source

Also Known As:

PDMP; 1-phenyl-2-decanoylamino-3-morpholino-1-propanol; 2-decanoylamino-3-morpholino-1-phenylpropanol; D-PDMP compound; D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol; DAMPP; RV 538, (R-(R*,R*))-isomer; RV-538; threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

Networked: 190 relevant articles (11 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - RV 538: 190

Experts

1.	Nomura, Shosaku: 15 articles (01/2019 - 02/2003)
2.	Shouzu, Akira: 8 articles (01/2012 - 07/2004)
3.	Iwasaka, Toshiji: 6 articles (11/2009 - 01/2004)
4.	Simoni-Wastila, Linda: 5 articles (01/2022 - 01/2017)
5.	Inokuchi, Jin-ichi: 5 articles (01/2016 - 02/2003)
6.	Inami, Norihito: 5 articles (01/2012 - 02/2009)
7.	Henry, Stephen G: 4 articles (12/2021 - 01/2019)
8.	Basu, Manju: 4 articles (01/2018 - 01/2004)
9.	Ma, Rui: 4 articles (01/2018 - 01/2004)
10.	Omoto, Seitarou: 4 articles (01/2012 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "However, evidence of PDMP impacts on patients with cancer remains limited. " 12/15/2021 - "PDMP-associated genes were mostly enriched in metabolism-associated pathways, suggesting the potential roles of methylation alternation in reprogramming cancer cell metabolism. " 09/13/2016 - "Intriguingly, PDMP treatments restored wild-type p53 expression in heterozygous R273H mutant cells and in tumors, decreasing CSCs and sensitizing cells and tumors to treatments. " 10/01/2014 - "Immunohistochemical analysis revealed that tumors in the PDMP group had fewer microvessels and lower proliferation activity compared with those of the control group. " 10/01/2014 - "The results suggested that PDMP is effective at inhibiting tumor growth and prolonging the survival time of tumor-bearing BALB/c nude mice. "
2.	Opioid-Related Disorders (Opiate Addiction) 09/01/2017 - "Continuing medical education is effective for improving clinician knowledge and confidence related to opioid misuse, abuse, and diversion and effective use of a PDMP; however, the education did not result in a significant increase in enrollment in state PDMPs." 10/01/2016 - "This study shows PDMP utility for measuring opioid addiction treatment outcomes, supporting the routine use of PDMPs in clinical and research settings. " 10/01/2016 - "This study examines Prescription Drug Monitoring Program (PDMP) tracking as a novel measure of opioid addiction treatment outcomes in a university-affiliated integrated mental health-addiction treatment clinic. " 10/13/2023 - "A chi-squared test was used to examine the association between risk according to (i) a PDMP alert and a clinical risk per ROOM; (ii) a PDMP alert and positive screening for opioid use disorder; and (iii) a PDMP 'high-dose' alert (average of >100 mg OME/day in the past 90 days) and any ROOM-validated risk. " 01/01/2023 - "I analyze the shortcomings of an ML system currently deployed in the USA to predict patients' likelihood of opioid addiction and misuse (PDMP algorithmic platforms). "
3.	Substance-Related Disorders (Drug Abuse) 01/01/2022 - "In the latter group, most physicians felt the PDMP had benefited their patient relationships by fostering dialogue around patient substance use; however, some used the PDMP to dismiss patients from care. " 01/01/2023 - "This study demonstrates self-report clinical measures of substance use can be cross-walked to PDMP data and translated into clinically interpretable information." 10/01/2020 - "Results from this study reveal that the implementation of PDMP has mitigated the issue of drug abuse and has increased work efficiency among healthcare practitioners. " 01/01/2020 - "This study explores the implementation of mandatory PDMP technology in primary care practice and the effects on treatment of people with possible substance use disorders. " 07/01/2011 - "This is the first study to examine Florida pharmacists' attitudes toward PDMP implementation, and the results should prompt future analyses of relevant outcomes, such as drug abuse, drug-related mortality, and doctor shopping."
4.	Pain (Aches) 03/01/2023 - "State-sponsored insurance was associated with a higher odds of using PDMP and pain agreements with an odds ratio (OR) of 1.72 (0.97, 3.13), while alcohol misuse had a lower odds of using PDMP (OR 0.40). " 01/01/2021 - "In that year, 143 students wrote 7,001 PDMP notes, reviewed 6,130 UDS results, and documented 202 pain assessments. " 01/01/2021 - "Using personally owned laptops and VA cell phones, students performed prescription drug monitoring program (PDMP) activities, reviewed urine drug screening (UDS) results, called patients to assess pain, and documented progress notes. " 10/01/2019 - "Sensitivity analyses assessed the general Medicare sample regardless of pain diagnoses, individual PDMP characteristics, and compared GEE model findings to models with state fixed effects. " 04/01/2019 - "We conducted 16 in-depth semi-structured interviews with practicing emergency and pain physicians regarding their procedures, problems, and proposed solutions surrounding their use of CURES, California's PDMP. "
5.	Atherosclerosis 11/01/2003 - "Activated microparticles and PDMP may contribute to the development of atherosclerosis in diabetes, and platelet activation markers seem to be useful for the assessment of vascular damage in these patients." 01/01/2011 - "Platelet-derived microparticles (PDMP), selectins, and adiponectin play an important role in the development of atherosclerosis in diabetes. " 11/01/2009 - "Platelet-derived microparticles (PDMP), selectins, and adiponectin play an important role in the development of atherosclerosis in diabetes. " 02/01/2009 - "However, the influence of EPA and statins on PDMP and adiponectin in atherosclerosis is poorly understood. " 02/01/2009 - "Platelet-derived microparticles (PDMP) play an important role in the pathogenesis of diabetic vasculopathy, and statins or eicosapentaenoic acid (EPA) have been shown to have a beneficial effect on atherosclerosis in hyperlipidemic patients. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	RV 538 (PDMP)
3.	Opioid Analgesics (Opioids)
4.	Ceramides
5.	Controlled Substances
6.	Glycosphingolipids
7.	Glucosylceramides (Glucocerebrosides)
8.	G(M3) Ganglioside
9.	CDw17 antigen (lactosylceramide)
10.	Therapeutic Uses

Related Therapies and Procedures

1.	Therapeutics
2.	Postoperative Care
3.	Tonsillectomy
4.	Life Support Care
5.	Renal Dialysis (Hemodialysis)