vineomycin A1

from Streptomyces strain No. 1894; structure in second source

Also Known As:

OS-4742A(1); OS-4742A1; P-1894B; Benz(a)anthracene-1,7,12(2H)-trione, 9-(2,6-dideoxy-4-O-(5-((5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)-beta-arabino-hexopyranosyl)-3-((5-((5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-3,4,4a,12b-tetrahydro-4a,8,12b-trihydroxy-3-methyl-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kitamura, Takashi: 1 article (11/2019)
2.	Kuriki, Hajime: 1 article (11/2019)
3.	Matsumoto, Yuka: 1 article (11/2019)
4.	Takahashi, Daisuke: 1 article (11/2019)
5.	Toshima, Kazunobu: 1 article (11/2019)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/15/2019 - "Structure-activity relationship studies for cytotoxicity against human breast cancer MCF-7 cells using several synthetic vineomycin A1 analogues differing in the number and position of glycon moieties revealed that the cytotoxicity increased as the number of glycon moieties increased. "
2.	Hypertrophic Cicatrix (Hypertrophic Scar) 11/01/1985 - "These results suggest that collagen prolyl hydroxylase inhibitor P-1894B may be a suitable agent for topical treatment of hypertrophic scar tissue or keloid."
3.	Keloid 11/01/1985 - "These results suggest that collagen prolyl hydroxylase inhibitor P-1894B may be a suitable agent for topical treatment of hypertrophic scar tissue or keloid."
4.	Hypertension (High Blood Pressure) 01/01/1984 - "Treatment with P-1894B significantly inhibited prolyl hydroxylase activity, reduced arterial collagen synthesis, but did not prevent or reverse hypertension." 01/01/1984 - "Changes in arterial collagen synthesis and the effects of P-1894B, a potent inhibitor of prolyl hydroxylase, were investigated on rat hypertension, induced by deoxycorticosterone acetate (DOCA) and salt. "
5.	Granuloma 11/01/1985 - "P-1894B an inhibitor of collagen prolyl hydroxylase was applied topically to cotton pellet-induced granuloma and to skin lesions in rats. "

Related Drugs and Biologics

1.	Prolyl Hydroxylases (Prolyl Hydroxylase)
2.	Collagen
3.	Prolyl-Hydroxylase Inhibitors
4.	Desoxycorticosterone Acetate (DOCA)
5.	Salts
6.	Desoxycorticosterone (Deoxycorticosterone)
7.	Acetates (Acetic Acid Esters)

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