meobentine

RN given refers to parent cpd; structure in first source

Also Known As:

Rythmatine; bis(N-4-methoxybenzyl-N',N''-dimethylguanidine)sulphate; meobentine sulfate; meobentine sulfate (2:1); meobentine sulphate

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - Methylguanidine: 80
      - meobentine: 4

Related Diseases

1.	Cardiac Arrhythmias (Arrythmia) 07/01/1984 - "The antiarrhythmic efficacy of meobentine was assessed by a comparison of arrhythmia frequency during placebo given on days just prior to meobentine. "
2.	Ventricular Tachycardia 10/01/1985 - "Meobentine sulfate: antiarrhythmic and electrophysiologic effects assessed by programmed electrical stimulation and ambulatory monitoring in patients with complex ventricular tachyarrhythmia. " 06/01/1984 - "These results suggest that while meobentine sulfate significantly increases the electrical VFT, it does not protect the conscious canine from the induction of ventricular tachyarrhythmias in response to PES, and it does not prevent VF in a conscious canine model of sudden coronary death.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1985 - "Five cardiology centers conducted open-label prospective trials of meobentine sulfate, an intravenously and orally available analog of bethanidine, to assess its potential for treatment of recurrent, drug refractory ventricular tachycardia (VT) or fibrillation (VF), and complex ventricular arrhythmias. "
3.	Tachycardia (Tachyarrhythmias) 11/01/1986 - "In studies of ouabain-induced tachycardias and 24-h infarct-induced ventricular arrhythmias, bethanidine tends to increase heart rate and/or exacerbate the ectopic activity (due to its sympathomimetic effects), whereas meobentine tends to reduce heart rate and restore normal sinus rhythm. "
4.	Infarction (Infarctions) 11/01/1986 - "In studies of ouabain-induced tachycardias and 24-h infarct-induced ventricular arrhythmias, bethanidine tends to increase heart rate and/or exacerbate the ectopic activity (due to its sympathomimetic effects), whereas meobentine tends to reduce heart rate and restore normal sinus rhythm. "
5.	Ventricular Fibrillation 11/01/1986 - "Finally, moderate increases of ventricular fibrillation threshold following treatment with meobentine are accompanied by partial cardiac sympathetic blockade, as indicated by reduced chronotropic responses to stellate ganglion stimulation. " 06/01/1984 - "After meobentine sulfate administration, eight of nine animals had sustained VT and one animal developed ventricular fibrillation (VF). " 06/01/1984 - "Intravenous meobentine sulfate, administered in dosages of 5.0, 10,0, and 20.0 mg/kg, produced a dose-related increase in the ventricular fibrillation threshold (VFT) under nonischemic conditions (7.6 +/- 1.8 mA vs 37.8 +/- 8.6 mA) (20 mg/kg; p less than 0.05) and during regional myocardial ischemia (5.6 +/- 1.5 mA vs 41.8 +/- 9.1 mA) (20 mg/kg; p less than 0.05). " 11/01/1986 - "Both bethanidine and meobentine increase ventricular fibrillation threshold. "

Related Drugs and Biologics

1.	Bethanidine (Batel)
2.	Sympathomimetics (Sympathomimetic Amines)
3.	Ouabain (G Strophanthin)
4.	Adrenergic Agents (Adrenergic Drugs)

Related Therapies and Procedures

1.	Therapeutics