salsoline

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35 relevant articles (0 outcomes, 2 trials/studies) found for this Bio-Agent

Description: monomethylated metabolite of salsolinol; RN given refers to (S)-isomer; endogenous neurotoxin found in CSF of patients with Parkinson's disease

Also Known As:

1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; 7-O-methylsalsolinol; N-methyl-(R)-salsolinol; methylsalsolinol; salsoline hydrochloride; salsoline hydrochloride, (R)-isomer; salsoline hydrochloride, (S)-isomer; salsoline hydrochloride, hydrate (4:4:1)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

Alkaloids: 633

Salsoline Alkaloids

salsoline: 35

2-Ring Heterocyclic Compounds

Isoquinolines: 17

Tetrahydroisoquinolines: 33

salsoline: 35

Salsoline Alkaloids

salsoline: 35

Experts

1.	Naoi, Makoto: 2 articles (05/2004 - 09/2002)
2.	Maruyama, Wakako: 2 articles (05/2004 - 09/2002)
3.	Yi, Hong: 2 articles (05/2004 - 09/2002)
4.	Maruyama, W: 2 articles (01/2000 - 01/2000)
5.	Naoi, M: 2 articles (01/2000 - 01/2000)
6.	Jin, Litong: 1 article (04/2008)
7.	Zhang, Wen: 1 article (04/2008)
8.	Zhu, Wei: 1 article (04/2008)
9.	Zheng, Jiaohong: 1 article (04/2008)
10.	Wang, Dan: 1 article (04/2008)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2000 - "These results suggest that N-methyl(R)salsolinol and a neutral N-methyltransferase may be endogenous factors in the pathogenesis of Parkinson's disease." 01/01/2000 - "N-methyl(R)salsolinol and a neutral N-methyltransferase as pathogenic factors in Parkinson's disease." 06/04/1999 - "An endogenous neurotoxin, N-methyl(R)salsolinol, has been proved to be involved in the pathogenesis of Parkinson's disease" 06/13/1998 - "N-methyl-(R)-salsolinol and Parkinson's disease." 03/21/1998 - "N-methyl-(R)-salsolinol and its relevance to Parkinson's disease." Get all the results and reference details, order at left...
2.	Parkinsonian Disorders (Parkinsonism) 01/01/1998 - "1(R), 2(N)-Dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, is a potent dopaminergic neurotoxin to induce parkinsonism in rats" 02/14/1997 - "N-Methyl(R)salsolinol was found to be an endogenous dopaminergic neurotoxin inducing parkinsonism in rodents and to increase in the cerebrospinal fluid of parkinsonian patients" 01/01/2001 - "Endogenous N-methyl(R)salsolinol, which caused parkinsonism in rats by injection in the striatum, was found to induce apoptosis in dopaminergic neuroblastoma SH-SY5Y cells" 07/01/1995 - "Recently, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [N-methyl-(R)salsolinol, NM(R)Sal] and 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion [DiMeDHIQ+] were found to cause a syndrome similar to parkinsonism in rodents" 01/01/2000 - "As an endogenous MPTP-like neurotoxin, N-methyl(R)salsolinol was proved to induce parkinsonism in rats and apoptosis in dopaminergic neurons" Get all the results and reference details, order at left...
3.	Neuroblastoma 05/21/2004 - "Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells." 09/01/2002 - "N-Methyl( R)salsolinol induced apoptosis in human dopaminergic neuroblastoma cells" 08/01/2002 - "The role of mitochondrial permeability transition (PT) in apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol [NM(R)Sal], was studied by use of dopaminergic neuroblastoma SH-SY5Y cells" 01/01/2000 - "An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, stereo-selectively induced apoptosis in human neuroblastoma SH-SY5Y cells" 09/05/1997 - "A neurotoxin N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells." Get all the results and reference details, order at left...
4.	DNA Damage 08/01/2001 - "Overexpression of Bcl-2 prevented the decline in DeltaPsim and also apoptotic DNA damage induced by N-methyl(R)salsolinol" 09/05/1997 - "Using a single cell gel electrophoresis (comet) assay, DNA damage was quantitatively measured, and it was found to depend on the concentration of N-methyl(R)salsolinol and the incubation time up to 6 h" 07/01/1997 - "An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells." 01/01/1997 - "N-Methyl-(R)salsolinol depleted dopamine neurons in the rat substantia nigra without necrotic tissue reaction, which may be due to the apoptotic death process, as proved by its induction of DNA damage in dopaminergic neuroblastoma SH-SY5Y cells" 01/01/1998 - "N-Methyl(R)salsolinol induced DNA damage to human neuroblastoma SH-SY5Y cells, which could be prevented by anti-oxidants and cycloheximide" Get all the results and reference details, order at left...
5.	Hypokinesia (Bradykinesia) 02/19/1996 - "Among salsolinol analogs examined, only N-methyl-(R)- salsolinol (NM(R)Sal) induced behavioral changes very similar to those in Parkinson's disease: hypokinesia, stiff tail, limb twitching at rest and postural abnormality" Get all the results and reference details, order at left...
8 Diseases and 35 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Neurotoxins
3.	1,2,3,4-tetrahydroisoquinoline
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.	salsolinol
6.	Isoquinolines
7.	catechol (pyrocatechol)
8.	Enzymes
9.	salsolinol N-methyltransferase
10.	isoquinoline
27 Drugs and Important Bio-Agents and 21 more articles analyzed in the Research Interface, order at left...

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