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keyhole-limpet hemocyanin (keyhole limpet hemocyanin)

large MW protein antigen from hemolymph of the keyhole limpet; used extensively to evaluate primary cellular & humoral immune responses in humans
Also Known As:
keyhole limpet hemocyanin; KLH antigen; immunocyanine; keyhole-limpet haemocyanin; keyhole-limpet hemacyanin
Networked: 418 relevant articles (23 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Livingston, Philip O: 11 articles (01/2012 - 10/2003)
2. Ragupathi, Govind: 10 articles (01/2012 - 10/2003)
3. Figdor, Carl G: 8 articles (03/2013 - 11/2003)
4. Adema, Gosse J: 7 articles (03/2013 - 11/2003)
5. Lesterhuis, W Joost: 7 articles (03/2013 - 11/2003)
6. de Vries, I Jolanda M: 7 articles (03/2013 - 11/2003)
7. Punt, Cornelis J A: 6 articles (01/2013 - 11/2003)
8. McFadden, David W: 6 articles (11/2007 - 11/2003)
9. Kwak, Larry W: 5 articles (06/2012 - 06/2006)
10. Hood, Chandra: 5 articles (01/2012 - 11/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Urinary Bladder Neoplasms (Bladder Cancer)
3. Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
06/01/2012 - "When conjugated to the immune carrier keyhole limpet hemocyanin (KLH), vaccination with an idiotype protein vaccine has been able to improve length of freedom from disease relapse in patients with follicular lymphoma (FL) in a minimal residual disease (MRD) state after induction therapy, as demonstrated in a recent randomized, controlled phase III trial. "
06/20/2009 - "To evaluate patient-specific immunotherapy with mitumprotimut-T (idiotype keyhole limpet hemocyanin [Id-KLH]) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in CD20(+) follicular lymphoma. "
06/01/2006 - "Administration of autologous tumor-derived idiotype protein conjugated to a carrier protein, keyhole limpet hemocyanin, together with granulocyte-macrophage colony-stimulating factor to follicular lymphoma patients in complete clinical remission was associated with induction of tumor-specific cellular and humoral immunity, molecular remissions, and prolonged disease-free survival. "
06/01/2011 - "Early stage clinical studies revealed that vaccination consisting of keyhole limpet hemocyanin-conjugated lymphoma idiotype protein in combination with granulocyte-macrophage colony-stimulating factor induced tumor-specific immune responses and molecular remission in patients with follicular lymphoma. "
07/10/2011 - "Vaccination with hybridoma-derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monocyte colony-stimulating factor (GM-CSF) induces follicular lymphoma (FL) -specific immune responses. "
4. Melanoma (Melanoma, Malignant)
5. Transitional Cell Carcinoma

Related Drugs and Biologics

1. Antibodies
2. Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
3. Antigens
4. QS 21 (QS21)
5. Vaccines
6. Ethoglucid (Etoglucid)
7. Peptides
8. Immunologic Adjuvants (Immunologic Adjuvant)
9. Freund's Adjuvant
10. Bovine Serum Albumin

Related Therapies and Procedures

1. Immunotherapy
2. Injections
3. Drug Therapy (Chemotherapy)
4. Intravesical Administration
5. Subcutaneous Injections