|1.||Ulbrich, Karel: 29 articles (02/2015 - 05/2002)|
|2.||Ghandehari, Hamidreza: 23 articles (05/2015 - 01/2004)|
|3.||Kopecková, Pavla: 19 articles (04/2010 - 01/2002)|
|4.||Kopecek, J: 19 articles (03/2008 - 01/2000)|
|5.||Kopecek, Jindrich: 18 articles (04/2010 - 01/2002)|
|6.||Kopecková, P: 16 articles (03/2008 - 01/2000)|
|7.||Kopeček, Jindřich: 15 articles (11/2015 - 07/2011)|
|8.||Ulbrich, K: 14 articles (08/2014 - 02/2000)|
|9.||Ríhová, Blanka: 14 articles (12/2013 - 05/2002)|
|10.||Wang, Dong: 12 articles (01/2016 - 07/2006)|
01/01/2003 - "Drug-HPMA-HuIg conjugates effective against human solid cancer."
07/01/2014 - "N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. "
03/01/2012 - "Preliminary evaluation of the efficacy of the conjugates in vivo show tumor growth inhibition for all HPMA copolymer/DTX conjugates."
11/28/2013 - "PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo: a quantitative study using radiolabeling and positron emission tomography."
01/01/2014 - "The targeted transduction of MMP-overexpressing tumor cells by ACPP-HPMA copolymer-coated adenovirus conjugates."
02/28/2013 - "In vitro studies on human ovarian carcinoma A2780 cells were carried out to investigate the cytotoxicity of free PTX, HPMA copolymer-PTX conjugate with Mw of 48 kDa (P-PTX), and mP-PTX. "
07/01/1999 - "To study peculiarities and the mechanism of the anticancer effect of free and HPMA copolymer-bound ADR in sensitive and resistant human ovarian carcinoma cells. "
02/01/2013 - "The examination of molecular-weight-dependent antitumor activity toward human ovarian A2780/AD carcinoma in nude mice reveals enhanced activity of multiblock, second-generation, higher molecular weight conjugates when compared with traditional HPMA copolymer-DOX conjugates. "
03/01/2012 - "Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates."
08/28/2003 - "Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells."
03/01/2014 - "An (111)In labeled HPMA copolymer system for single photon emission computerized tomography (SPECT) was developed to observe the biodistribution changes associated with hyperthermia. "
03/01/2014 - "Efficacy studies were conducted in prostate tumor bearing mice using the (90)Y HPMA copolymer with hyperthermia. "
03/01/2014 - "The greatest reduction in tumor growth was observed in the hyperthermia treated tumors with (90)Y HPMA copolymer conjugates. "
02/26/2007 - "In an attempt to improve the tumor accumulation of HPMA copolymer-based drug delivery systems, their in vivo application was combined with radiotherapy and hyperthermia. "
02/26/2007 - "Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems."
|4.||Prostatic Neoplasms (Prostate Cancer)
06/01/2009 - "Results of in vitro activity and in vivo tolerability experiments hold promise for the utility of HPMA copolymer-AH-GDM-RGDfK conjugates for treatment of prostate cancer with greater efficacy and reduced toxicity."
05/10/2011 - "Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy."
12/01/2010 - "HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer."
04/02/2010 - "Endocytic uptake and subcellular trafficking of a large array of HPMA (N-(2-hydroxypropyl)methacrylamide) based copolymers possessing positively or negatively charged residues, or hydrophobic groups were evaluated by flow cytometry and living cell confocal microscopy in cultured prostate cancer cells. "
11/01/2009 - "Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery."
|5.||T-Cell Lymphoma (Lymphoma, T Cell)
08/01/2010 - "In this study, we demonstrate that Dox-HPMA(AM) treatment changes glycosylation of the EL4 T cell lymphoma surface and sensitizes the cells to galectin-1-induced apoptosis."
10/01/2003 - "In contrast to the low antitumor activity of free doxorubicin and nontargeted HPMA copolymer-doxorubicin conjugate, both anti-Thy-1.2 targeted conjugates (classic and starlike) cured all mice bearing T-cell lymphoma EL4. "
12/28/2012 - "Biodistribution of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-DOX conjugates of linear and star architectures were compared in EL4 T-cell lymphoma-bearing mice. "
12/01/2011 - "Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma."
01/01/2013 - "Treatment of murine EL4 T cell lymphoma with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates of doxorubicin (Dox) leads to complete tumor regression and to the development of therapy-dependent longlasting cancer resistance. "
|6.||meso-chlorin e(6) monoethylene diamine
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Photochemotherapy (Photodynamic Therapy)
|4.||Drug Therapy (Chemotherapy)