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fenobam

in USAN fenobam refers to monohydrate

Also Known As:

fenobam anhydrous; fenobam monohydrate; Urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-

Networked: 15 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - fenobam: 15

Experts

1.	Gereau, Robert W: 4 articles (01/2020 - 09/2009)
2.	Cavallone, Laura F: 3 articles (01/2020 - 09/2009)
3.	Montana, Michael C: 3 articles (01/2020 - 09/2009)
4.	Danysz, Wojciech: 3 articles (01/2015 - 08/2009)
5.	Kharasch, Evan D: 2 articles (01/2020 - 09/2009)
6.	Bezard, Erwan: 2 articles (05/2014 - 09/2010)
7.	Li, Qin: 2 articles (05/2014 - 09/2010)
8.	Arakawa, Ryosuke: 1 article (01/2020)
9.	Cselényi, Zsolt: 1 article (01/2020)
10.	Doshi, Tina: 1 article (01/2020)

Related Diseases

1.	Pain (Aches) 12/01/2011 - "Fenobam represents a promising candidate for the treatment of human pain conditions." 01/01/2020 - "Fenobam is analgesic in numerous mouse pain models, acting exclusively through mGlu5 blockade. " 01/01/2020 - "A second investigation tested the analgesic effects of fenobam in an established experimental human pain model of cutaneous sensitization using capsaicin cream and heat, in a double-blind placebo-controlled study. " 09/01/2009 - "We show that fenobam reduces formalin-induced pain behaviors and relieves established inflammation-induced thermal hypersensitivity in mice. "
2.	Fragile X Syndrome (Martin Bell Syndrome) 04/01/2009 - "A pilot open label, single dose trial of fenobam, an mGluR5 antagonist, was conducted to provide an initial evaluation of safety and pharmacokinetics in adult males and females with fragile X syndrome (FXS). " 04/01/2009 - "A pilot open label, single dose trial of fenobam in adults with fragile X syndrome." 12/01/2014 - "Fenobam is a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5) with inverse agonist activity and is expected to contribute to the treatment of neuropsychiatric disorders involving dysfunction of mGluR5 including Fragile X syndrome. "
3.	Cocaine-Related Disorders (Cocaine Addiction) 09/01/2013 - "This study provides additional support for the role of mGluR5 signaling in cocaine addiction and suggests that fenobam sulfate may have translational potential in medication development for the treatment of cocaine addiction in humans."
4.	Schizophrenia (Dementia Praecox) 01/01/2023 - "The aim of our study was to investigate the behavioral and molecular changes by using the mGlu1 receptor positive allosteric modulator (PAM) agent RO 67-7476, and the negative allosteric modulator (NAM) agent JNJ 16259685 and the mGlu5 receptor PAM agent VU-29, and NAM agent fenobam in the Poly I:C-induced schizophrenia model in rats. "
5.	Ischemia 01/01/2015 - "In the present study, we examined the effects of negative and positive allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), fenobam and ADX47273, respectively, on brain damage induced by hypoxia-ischemia (H-I) in 7-day-old rats. "

Related Drugs and Biologics

1.	Metabotropic Glutamate 5 Receptor
2.	Sulfates (Sulfates, Inorganic)
3.	Poly I-C
4.	Capsaicin (Zostrix)
5.	Analgesics (Analgesic Drugs)
6.	S- (4- fluorophenyl)- (3- (3- (4- fluorophenyl)- (1,2,4)- oxadiazol- 5- yl)piperidin- 1- yl)methanone
7.	Formaldehyde (Formol)
8.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
9.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
10.	Urea (Carbamide)