|1.||Rasul, Azhar: 5 articles (10/2014 - 01/2012)|
|2.||Khan, Muhammad: 4 articles (10/2014 - 01/2012)|
|3.||Ma, Tonghui: 3 articles (10/2014 - 01/2012)|
|4.||Ali, Muhammad: 3 articles (10/2013 - 01/2013)|
|5.||Zhong, Lili: 2 articles (10/2014 - 01/2012)|
|6.||Li, Xiaomeng: 2 articles (01/2013 - 01/2013)|
|7.||Li, Jiang: 2 articles (01/2013 - 01/2013)|
|8.||Li, Yuzhong: 1 article (11/2014)|
|9.||Meng, Xiuxiang: 1 article (11/2014)|
|10.||Liu, Yong: 1 article (11/2014)|
|1.||BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
|2.||Acute Erythroblastic Leukemia (Erythroleukemia)
10/01/2013 - "Isoalantolactone-induced cytotoxicity and apoptosis of SGC-7901 cells involve mitochondria-caspase and PI3K/Akt dependent pathways, which gives the rationale for in vivo studies on the utilization of Isoalantolactone as a potential cancer therapeutic compound."
11/01/2014 - "It has been reported that isoalantolactone has the capacity to inhibit tumor cell growth through induction of apoptosis. "
10/01/2014 - "Isoalantolactone, isolated from Inula spp., has been reported to inhibit the growth of several types of cancer cells. "
01/01/2013 - "Isoalantolactone, a medicinal plant-derived natural compound, is known to induce apoptosis in various cancer cell lines. "
01/01/2013 - "Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. "
|4.||Osteosarcoma (Osteogenic Sarcoma)
10/01/2014 - "The present study is the first to investigate the effects of isoalantolactone on cell viability in human osteosarcoma U2OS, MG-63 and Saos-2 cells, and its mechanism of action in U2OS cells. "
10/01/2014 - "Taken together, our data demonstrated that isoalantolactone induces ROS-dependent apoptosis in U2OS cells via a novel mechanism involving inhibition of NF-κBp65 and provide the rationale for further in vivo and preclinical investigation of isoalantolactone against osteosarcoma. "
10/01/2014 - "However, no prior research has been conducted to demonstrate the antiproliferative potential of isoalantolactone on osteosarcoma. "
10/01/2014 - "We also found that isoalantolactone-induced apoptosis was associated with the downregulation of Bcl-2 and upregulation of Bax, which finally led to the activation of caspase-3 and its downstream substrate, PARP, in osteosarcoma U2OS cells. "
10/01/2014 - "Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction."
|5.||Pancreatic Neoplasms (Pancreatic Cancer)
|2.||Reactive Oxygen Species (Oxygen Radicals)
|3.||Caspase 3 (Caspase-3)
|1.||Drug Therapy (Chemotherapy)