|1.||Puil, Ernest: 3 articles (12/2015 - 04/2010)|
|2.||Yu, Wilson: 3 articles (07/2015 - 11/2011)|
|3.||Shin, Damian S: 3 articles (07/2015 - 11/2011)|
|4.||Puil, E: 3 articles (05/2015 - 12/2009)|
|5.||Schwarz, Stephan K W: 2 articles (12/2015 - 04/2010)|
|6.||MacLeod, Bernard A: 2 articles (12/2015 - 04/2010)|
|7.||Smith, Autumn B: 2 articles (07/2015 - 02/2014)|
|8.||MacLeod, B A: 2 articles (05/2015 - 06/2012)|
|9.||Schwarz, S K W: 2 articles (05/2015 - 06/2012)|
|10.||Cooke, J E: 2 articles (06/2012 - 12/2009)|
|1.||Decompression Sickness (Bends)
01/01/1995 - "The results obtained confirm the conclusions from previous studies, namely that beta-bends and 3(10)-helices are preferentially adopted by isovaline-rich peptides, a clear indication that this C alpha, alpha-disubstituted glycine tends to induce folded structures much more extensively than its unmethylated parent compound alpha-aminobutyric acid. "
07/10/2015 - "We are the first to demonstrate that isovaline may be a plausible anti-seizure drug for secondarily generalized seizures and this could potentially lead to the development of a novel class of anti-seizure drugs focused around the unique mechanism(s) of isovaline."
07/10/2015 - "Recently we reported that isovaline, a unique amino acid, could attenuate seizure like events (SLEs) in two in vitro hippocampal seizure models by selectively increasing the activity of interneurons, but not pyramidal neurons. "
02/01/2014 - "Isovaline, a unique amino acid, was shown to attenuate seizure-like events (SLEs) in two in vitro hippocampal seizure models by selectively increasing the activity of interneurons, but not pyramidal neurons. "
11/01/2011 - "Coapplication of 4-AP and isovaline increased interneuronal spontaneous spiking from 1.0 ± 0.6 to 2.6 ± 0.8 Hz, whereas pyramidal neuronal spiking activity decreased from 0.6 ± 0.4 to 0.2 ± 0.1 Hz. Isovaline exhibited anticonvulsant properties in two hippocampal seizure models. "
11/01/2011 - "Similar effects were seen with isovaline in the 4-AP seizure model. "
04/01/2010 - "Isovaline reduced responses in mouse pain models without producing acute toxicity, possibly by enhancing receptor modulation of nociceptive information."
12/15/2009 - "The rare amino acid isovaline has analgesic properties in pain models and is a structural analogue of the inhibitory neurotransmitter glycine. "
|5.||Body Weight (Weight, Body)
01/01/2013 - "Pah(enu2) and control mice were intraperitoneally administered (500-750 mg/kg body weight, once daily; standard 19% protein diet) AIB, methyl AIB (MAIB), isovaline, and two MAIB analogs, 2-methyl-2-(methylamino)butanoic (MeVal) and 3-methyl-2-(methylamino)pentanoic (MePent) acids for one week, followed by brain and blood isolation for amino acid analyses using UPLC. "
09/01/2013 - "Vehicle-treated controls were used in addition to intraperitoneal injections of 1, 10 and 100mg/kg body weight of each, alpha-amino-isobutyic acid (AIB), isovaline (IVA), alpha-propyl-alanine (APA), alpha-butyl-alanine (ABA), alpha-pentyl-alanine (APnA), alpha-ethylphenylglycine (AEPG) and alpha-methyl-valine (AMV). "
|1.||Glycine (Aminoacetic Acid)
|3.||butyrine (alpha-aminobutyric acid)
|4.||4-Aminopyridine (4 Aminopyridine)
|5.||Glutamic Acid (Glutamate)
|6.||Neurotransmitter Agents (Neurotransmitter)