LY 53857

RN given refers to maleate[1:1](8beta)-isomer

Also Known As:

LY-53857; Lilly 53857; ergoline-8-carboxylic acid, 6-methyl-1-(1-methylethyl)-, 2-hydroxy-1-methylpropyl ester, (8beta)-, (2Z)-2-butenedioate (1:1)

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Ergot Alkaloids: 208
    - Ergolines: 109
      - LY 53857: 14
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Ergolines: 109
      - LY 53857: 14

Experts

1.	Inoue, K: 2 articles (09/2003 - 08/2001)
2.	Sugimoto, Y: 2 articles (09/2003 - 08/2001)
3.	Yamada, J: 2 articles (09/2003 - 08/2001)
4.	Homma, Ikuo: 1 article (07/2009)
5.	Kanamaru, Mitsuko: 1 article (07/2009)
6.	Inoue, Kiyo: 1 article (09/2003)
7.	Sugimoto, Yumi: 1 article (09/2003)
8.	Yamada, Jun: 1 article (09/2003)
9.	Kunitomo, M: 1 article (08/2001)
10.	Ohkura, M: 1 article (08/2001)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 06/12/1992 - "In rats with SAD, 5-HT produced a larger increase in blood pressure and a marked tachycardia, both of which were eliminated by the 5-HT2/1C antagonist LY 53857. " 12/01/1992 - "Pretreatment with the 5-HT2/5-HT1C receptor antagonists, cinanserin (300 nmol kg-1, i.c.v.) or LY 53857 (300 nmol kg-1, i.c.v.) reversed the initial bradycardia and sympathoinhibition to tachycardia and sympathoexcitation. " 01/01/1988 - "In pithed spontaneously hypertensive rats, the tachycardia to 5-HT was abolished by a combination of the 5-HT2 receptor antagonist LY 53857 and propranolol, suggesting that the tachycardia is mediated by 5-HT2 receptors and by release of noradrenaline. "
2.	Hyperglycemia 10/23/1990 - "Pretreatment with LY 53857 diminished alpha-methyl-5-HT-induced hyperglycemia. " 09/01/2003 - "induced dose-dependent hyperglycemia, which was enhanced by pretreatment with 5-HT (1/2/5/7) receptor antagonist methysergide and 5-HT (2A/2B/2C) receptor antagonist LY 53857. " 09/01/2003 - "The 5-HT(1/2/5/7)-receptor antagonist methysergide and the 5-HT(2A/2B/2C)-receptor antagonist LY 53857 enhanced clomipramine-induced hyperglycemia, while the 5-HT(1A/1B)-receptor antagonist (-)-propranolol and the 5-HT(3/4)-receptor antagonist tropisetron did not affect it. " 10/23/1998 - "p-Chloroamphetamine-induced hyperglycemia was prevented by methysergide, which blocks the 5-HT1 and 5-HT2 receptor, the 5-HT1A/1B/2C receptor antagonist, (-)-propranolol, the selective 5-HT1A receptor antagonist, 4-(2'-methoxyphenyl-1-[2'-n-2"pyridinyl)-p-iodobenzamido]-ethyl-pi perazine (p-MPPI), the 5-HT2A/2B/2C receptor antagonists, ritanserin and 4-isopropyl-7-methyl-9-(2-hydroxy-1-methyl-propoxycarbonyl)-4,6A,7 ,8,9,10,10A-octahydro-indolo[4,3-FG]quinolone maleate(LY 53857). "
3.	Bradycardia 12/01/1992 - "Pretreatment with the 5-HT2/5-HT1C receptor antagonists, cinanserin (300 nmol kg-1, i.c.v.) or LY 53857 (300 nmol kg-1, i.c.v.) reversed the initial bradycardia and sympathoinhibition to tachycardia and sympathoexcitation. " 06/01/1991 - "The selective 5-HT2 antagonist LY 53857 abolished the increase in MAP and the bradycardia elicited by 5-HT. " 12/01/1987 - "HR tended to decrease, but a significant bradycardia was observed only 15 min after 3 mg/kg. The selective 5-HT2 antagonist LY 53857 (1 mg/kg i.v.) did not affect MAP, HR or PRA per se, but at 0.03 to 1.0 mg/kg totally abolished the pressor response to quipazine (3 mg/kg). " 07/10/1992 - "Each of the 5-HT3 receptor selective antagonists (ICS 205-930 or MDL 72222) produced a dose-dependent attenuation of the Bezold-Jarisch reflex-mediated hypotension and bradycardia, and each of the 5-HT2 receptor selective antagonists (xylamidine, ketanserin or LY 53857) produced a dose-dependent attenuation of the pressor response. "
4.	Ischemia 10/01/1993 - "We determined the effect of the 5-HT2 receptor antagonists cinanserin (0.1-10 microM), ketanserin (0.3-10 microM), and LY 53857 (1-10 microM) on time to contracture, recovery of contractile function, and lactate dehydrogenase (LDH) release after 25-min global ischemia and 30-min reperfusion in isolated rat heart. "
5.	Hypotension (Low Blood Pressure) 07/10/1992 - "Each of the 5-HT3 receptor selective antagonists (ICS 205-930 or MDL 72222) produced a dose-dependent attenuation of the Bezold-Jarisch reflex-mediated hypotension and bradycardia, and each of the 5-HT2 receptor selective antagonists (xylamidine, ketanserin or LY 53857) produced a dose-dependent attenuation of the pressor response. "

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Ketanserin
3.	Propranolol (Inderal)
4.	Methysergide (Sansert)
5.	Serotonin 5-HT2 Receptor Antagonists
6.	p-Chloroamphetamine
7.	Cinanserin
8.	Tropisetron (Navoban)
9.	5-HT3 Serotonin Receptors (5 HT3 Receptor)
10.	5-HT1A Serotonin Receptor