N-glycolylneuraminic acid

RN given refers to (all-D)-isomer

Also Known As:

GcNeu; N-glycoloylneuraminic acid; N-glycolylneuraminic acid, (alpha-D-Gal)-isomer; NGNA; D-glycero-D-galacto-2-Nonulosonic acid, 3,5-dideoxy-5-((hydroxyacetyl)amino)-

Networked: 85 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Sugar Acids: 4
      - Neuraminic Acids: 8
        N-glycolylneuraminic acid: 85
  - Acyclic Acids
    - Sugar Acids: 4
      - Neuraminic Acids: 8
        N-glycolylneuraminic acid: 85
Carbohydrates: 22023
- Amino Sugars: 110
  - Neuraminic Acids: 8
    - N-glycolylneuraminic acid: 85
- Sugar Acids: 4
  - Neuraminic Acids: 8
    - N-glycolylneuraminic acid: 85

Experts

1.	Varki, Ajit: 11 articles (01/2021 - 09/2005)
2.	Padler-Karavani, Vered: 8 articles (01/2020 - 12/2008)
3.	Chen, Xi: 7 articles (01/2021 - 01/2009)
4.	Yu, Hai: 6 articles (01/2021 - 01/2009)
5.	Kawanishi, Kunio: 3 articles (01/2021 - 10/2016)
6.	Leviatan Ben-Arye, Shani: 3 articles (01/2020 - 05/2014)
7.	Reuven, Eliran Moshe: 3 articles (01/2020 - 05/2014)
8.	Day, Christopher J: 2 articles (03/2022 - 01/2018)
9.	Jennings, Michael P: 2 articles (03/2022 - 01/2018)
10.	Paton, Adrienne W: 2 articles (03/2022 - 01/2018)

Related Diseases

1.	Inflammation (Inflammations) 06/06/2020 - "[Study on the correlation between dietary N-glycolylneuraminic acid intake and chronic inflammation state of body]." 06/06/2020 - "Objective: To explore the correlation between dietary N-glycolylneuraminic acid (Neu5Gc) intake and chronic inflammation state of body. " 01/01/2019 - "Exploring the Arctic Charr Intestinal Glycome: Evidence of Increased N-Glycolylneuraminic Acid Levels and Changed Host-Pathogen Interactions in Response to Inflammation." 01/10/2023 - "On the other hand, N-glycolylneuraminic acid (Neu5Gc) is a non-human Sia capable of potentiating cancer and inflammation in the human body. " 01/01/2018 - "Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis."
2.	Neuroblastoma 08/01/2012 - "The article reports on the historical use of mAbs and on very recent progress made in antitumor therapy using the anti-GD2 mAb and the antiganglioside mAbs, anti-N-glycolylneuraminic acid mAb and anti-Lewis mAb. Anti-GD2 is showing great promise in Phase III clinical trials in adjuvant treatment of neuroblastoma. "
3.	Neoplasms (Cancer) 05/01/2023 - "One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). " 01/01/2022 - "Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells." 01/10/2023 - "On the other hand, N-glycolylneuraminic acid (Neu5Gc) is a non-human Sia capable of potentiating cancer and inflammation in the human body. " 01/01/2017 - "Recent studies have shown a relationship between the level of the sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc) in red meat and its risk in cancer, cardiovascular and inflammatory diseases. " 01/01/2023 - "The presence of N-glycolylneuraminic acid (Neu5Gc), a non-human sialic acid in cancer patients, is currently attributed to the consumption of red meat. "
4.	Melanoma (Melanoma, Malignant) 03/01/1986 - "We have found the presence of gangliosides containing N-glycolylneuraminic acid in human melanoma tissues. " 02/01/1989 - "As antibody 32-27M detects N-glycolylneuraminic acid (NeuGc)-containing gangliosides, the effect of adding a number of different gangliosides to melanoma and astrocytoma cells cultured in the synthetic medium was studied. " 06/01/2001 - "The importance of ganglioside structure in the tumour-protective effect of GM3/VSSP vaccine was confirmed using GM3 containing N-glycolylneuraminic acid, a ganglioside absent in melanoma cells. " 08/01/1993 - "The expression of N-glycolylneuraminic acid (NeuGc)-containing gangliosides in human melanoma cells grown both in culture and as xenografts in athymic (nu/nu) mice was analyzed extensively with specific mouse monoclonal antibodies (MAbs). "
5.	Carcinoma (Carcinomatosis) 09/28/2014 - "Additionally, dietary intake of the non-human Sia N-glycolylneuraminic acid (Neu5Gc) leads to natural metabolic-glycoengineering of human carcinomas that accumulate and express Neu5Gc. " 02/01/1999 - "Serum and tissue specimens from healthy Wistar rats and from rats with Walker 256 carcinoma were analysed for N-acetyl and N-glycolylneuraminic acid by high performance liquid chromatography (HPLC) as per-O-benzoylated derivatives. " 02/01/1999 - "Analysis of N-acetyl and N-glycolylneuraminic acid in rat serum and tissues with Walker 256 carcinoma by high-performance liquid chromatography." 05/07/2014 - "N-Glycolylneuraminic acid (Neu5Gc) is a foreign immunogenic sugar in humans originating from the diet (e.g., red meat) and subsequently expressed on the cell surface, especially accumulating on carcinoma. " 05/01/2021 - "Red meat-derived sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc), promotes the risk of carcinoma and inflammation. "

Related Drugs and Biologics

1.	Heterophile Antigens
2.	Heme Oxygenase-1
3.	HLA Antigens (Human Leukocyte Antigens)
4.	Endothelial Protein C Receptor
5.	human THBD protein
6.	N-Acetylneuraminic Acid (Sialic Acid)
7.	Antigens
8.	Gangliosides
9.	Antibodies
10.	Polysaccharides (Glycans)

Related Therapies and Procedures

1.	Therapeutics