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8-aminoguanosine

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Guanosine: 1156
        8-aminoguanosine: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Guanosine: 1156
      - 8-aminoguanosine: 4
  - Ribonucleosides: 49
    - Guanosine: 1156
      - 8-aminoguanosine: 4

Experts

1.	Gillespie, Delbert G: 1 article (12/2016)
2.	Jackson, Edwin K: 1 article (12/2016)
3.	Mi, Zaichuan: 1 article (12/2016)

Related Diseases

1.	Hypertension (High Blood Pressure) 12/01/2016 - "Long-term radiotelemetry studies demonstrated that oral 8-aminoguanosine and 8-aminoguanine (5 mg/kg/day) suppressed deoxycorticosterone/salt-induced hypertension. " 11/01/2023 - "Chronic treatment with 8-aminoguanine attenuates hypertension in deoxycorticosterone/salt rats, prevents strokes, and increases lifespan in Dahl salt-sensitive rats on a high salt diet and attenuates the metabolic syndrome in rats; 8-aminoguanosine retards progression of pulmonary hypertension in rats and anemia and organ damage in sickle cell mice. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/01/1986 - "When tested as an inhibitor of 2'-deoxyguanosine phosphorolysis in intact human erythrocytes and MOLT-3 human T-cell lymphoblastic leukemia cells, 5'-deoxy-5'-iodo-9-deazainosine was equipotent with 8-aminoguanosine (which is a precursor for 8-aminoguanine, Ki = 2 X 10(-7) M). "
3.	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/01/2023 - "Chronic treatment with 8-aminoguanine attenuates hypertension in deoxycorticosterone/salt rats, prevents strokes, and increases lifespan in Dahl salt-sensitive rats on a high salt diet and attenuates the metabolic syndrome in rats; 8-aminoguanosine retards progression of pulmonary hypertension in rats and anemia and organ damage in sickle cell mice. "
4.	Stroke (Strokes) 11/01/2023 - "Chronic treatment with 8-aminoguanine attenuates hypertension in deoxycorticosterone/salt rats, prevents strokes, and increases lifespan in Dahl salt-sensitive rats on a high salt diet and attenuates the metabolic syndrome in rats; 8-aminoguanosine retards progression of pulmonary hypertension in rats and anemia and organ damage in sickle cell mice. "
5.	Neoplasms (Cancer) 05/01/1995 - "Repletion of the guanine nucleotide pools by coincubation of CEM cells with guanosine plus 8-aminoguanosine prevented both the inhibition of primer RNA synthesis and the inhibition of tumor cell growth induced by these agents. "

Related Drugs and Biologics

1.	Salts
2.	Desoxycorticosterone (Deoxycorticosterone)
3.	8-aminoguanine
4.	RNA (Ribonucleic Acid)
5.	Guanosine
6.	Guanine Nucleotides
7.	5'-deoxy-5'-iodo-9-deazainosine