|1.||Matousek, J: 8 articles (01/2010 - 03/2000)|
|2.||Soucek, J: 6 articles (01/2008 - 01/2000)|
|3.||Matousek, Josef: 5 articles (01/2010 - 02/2002)|
|4.||Pouckova, P: 4 articles (01/2010 - 03/2000)|
|5.||Poucková, P: 4 articles (01/2006 - 01/2001)|
|6.||Cinatl, J: 4 articles (03/2001 - 03/2000)|
|7.||Schwabe, D: 4 articles (03/2001 - 03/2000)|
|8.||Picone, Delia: 3 articles (05/2014 - 01/2011)|
|9.||D'Alessio, Giuseppe: 3 articles (01/2011 - 12/2002)|
|10.||Skvor, Jirí: 3 articles (01/2009 - 07/2002)|
05/01/2014 - "Altogether, our results shed more light on the mechanisms lying at the basis of BS-RNase antiproliferative effect in cancer cells, and support its potential use to develop new anti-cancer strategies. "
05/01/2014 - "Notably, to improve the autophagic response of cancer cells to BS-RNase we used two different strategies: the more basic (as compared to WT enzyme) G38K mutant of BS-RNase, known to interact more strongly than wt with the acidic membrane of cancer cells, or BS-RNase oligomerization (tetramerization or formation of larger oligomers). "
05/01/2014 - "Notably, we reveal for the first time that BS-RNase triggers Beclin1-mediated autophagic cancer cell death, providing evidences that high proliferation rate of cancer cells may render them more susceptible to autophagy by BS-RNase treatment. "
03/01/2000 - "Systemic administration of BS-RNase (12.5 mg/kg/day intraperitoneally, for 20 days in the course of four weeks) suppressed tumor growth but was not able to induce any cures. "
01/01/2000 - "Side by side with the ability of BS RNase to suppress the growth of human tumors transplanted to nude mice, these biological properties determine this enzyme as a promising agent with potential clinical application."
|2.||Melanoma (Melanoma, Malignant)
01/01/1998 - "administration of BS RNase to nude mice bearing melanoma showed even better results. "
01/01/1998 - "The intratumoral administration of BS RNase to nude mice bearing human melanoma showed a significant antitumor effect. "
01/01/1998 - "Human melanoma cells established in culture were extremely susceptible to BS RNase, administered in concentrations ranging from 1-100 microg/ml. Concentrations of BS RNase over 10 microg/ml caused complete inhibition of cell growth. "
01/01/1998 - "Based on our previous results, athymic mice bearing human melanoma or mouse seminoma were treated with intratumoral administration of BS RNase (12.5 mg/kg b.w.). "
01/01/1998 - "This paper reports on the antitumor activity of BS RNase on human melanoma and mouse seminoma. "
02/01/2002 - "In order to investigate the antitumoral efficacy of BS-RNase-PEG in vivo, preliminary experiments on the effect of the conjugate on neuroblastoma growth in mice were performed in a UKF-NB-3 xeno-transplantate model, demonstrating a drastically increased anti-tumoral activity of the conjugate compared to the free enzyme."
03/01/2000 - "In the present study, we tested the effects of BS-RNase on cultured neuroblastoma (NB) cells resistant to chemotherapeutic agents. "
03/01/2000 - "Bovine seminal ribonuclease exerts selective cytotoxicity toward neuroblastoma cells both sensitive and resistant to chemotherapeutic drugs."
03/01/2000 - "Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells."
01/01/2000 - "BS RNase 50 microg/ml was proven to induce 49.7, 54 and 68.1% apoptosis in the cells of the ML-2 myeloid cell line and two neuroblastoma cell lines: NB-1 and NB-2, respectively. "
|5.||Thyroid Neoplasms (Thyroid Cancer)
06/01/2003 - "The caspase inhibitor Z-Val-Ala-Asp-(OMe)-fluoromethylketone protected thyroid cancer cells from BS-RNase-induced apoptosis. "
03/01/2001 - "The cytotoxic effects of bovine seminal ribonuclease (BS-RNase) against thyroid carcinoma cell lines with different degrees of differentiation in comparison to non-malignant cells, including human foreskin fibroblasts (HFF) and retinal pigment epithelial cells (RPE), were tested using the MTT dye reduction assay. "
|2.||Pancreatic Ribonuclease (Ribonuclease A)
|6.||Protein Isoforms (Isoforms)
|7.||Double-Stranded RNA (RNA, Double Stranded)
|9.||Polyethylene Glycols (Polyethylene Glycol)
|10.||DNA (Deoxyribonucleic Acid)