ribonuclease SPL

RNase A-type activity on synthetic polyribonucleotides & Mg containing heat-denatured or Mg depleted undenatured E coli RNA, but gives a limited digest containing only large fragments with Mg containing native E coli RNA

Also Known As:

Networked: 32 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matousek, J: 8 articles (01/2010 - 03/2000)
2.	Soucek, J: 6 articles (01/2008 - 01/2000)
3.	Matousek, Josef: 5 articles (01/2010 - 02/2002)
4.	Pouckova, P: 4 articles (01/2010 - 03/2000)
5.	Poucková, P: 4 articles (01/2006 - 01/2001)
6.	Cinatl, J: 4 articles (03/2001 - 03/2000)
7.	Schwabe, D: 4 articles (03/2001 - 03/2000)
8.	Picone, Delia: 3 articles (05/2014 - 01/2011)
9.	D'Alessio, Giuseppe: 3 articles (01/2011 - 12/2002)
10.	Poucková, Pavla: 3 articles (01/2009 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2014 - "Altogether, our results shed more light on the mechanisms lying at the basis of BS-RNase antiproliferative effect in cancer cells, and support its potential use to develop new anti-cancer strategies. " 05/01/2014 - "Notably, we reveal for the first time that BS-RNase triggers Beclin1-mediated autophagic cancer cell death, providing evidences that high proliferation rate of cancer cells may render them more susceptible to autophagy by BS-RNase treatment. " 03/01/2000 - "Systemic administration of BS-RNase (12.5 mg/kg/day intraperitoneally, for 20 days in the course of four weeks) suppressed tumor growth but was not able to induce any cures. " 01/01/2000 - "The cytotoxic effect of bovine seminal ribonuclease on tumor cells is accompanied by the induction of apoptosis. " 01/01/1998 - "Five to seven doses of BS RNase were sufficient to eliminate tumors in all treated mice. "
2.	Melanoma (Melanoma, Malignant) 01/01/1998 - "The intratumoral administration of BS RNase to nude mice bearing human melanoma showed a significant antitumor effect. " 01/01/1998 - "Human melanoma cells established in culture were extremely susceptible to BS RNase, administered in concentrations ranging from 1-100 microg/ml. Concentrations of BS RNase over 10 microg/ml caused complete inhibition of cell growth. " 01/01/1998 - "Based on our previous results, athymic mice bearing human melanoma or mouse seminoma were treated with intratumoral administration of BS RNase (12.5 mg/kg b.w.). " 01/01/1998 - "This paper reports on the antitumor activity of BS RNase on human melanoma and mouse seminoma. " 07/18/2002 - "Aspermatogenic activity was studied histologically following subcutaneous injections of RNase A and BS-RNase conjugates in ICR mice, and the antitumor activity in athymic nude mice with growing human melanoma with i.p. "
3.	Neuroblastoma 03/01/2000 - "In the present study, we tested the effects of BS-RNase on cultured neuroblastoma (NB) cells resistant to chemotherapeutic agents. " 03/01/2000 - "Bovine seminal ribonuclease exerts selective cytotoxicity toward neuroblastoma cells both sensitive and resistant to chemotherapeutic drugs." 03/01/2000 - "Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells." 01/01/2000 - "BS RNase 50 microg/ml was proven to induce 49.7, 54 and 68.1% apoptosis in the cells of the ML-2 myeloid cell line and two neuroblastoma cell lines: NB-1 and NB-2, respectively. " 11/01/1999 - "Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis."
4.	Malignant Mesothelioma 12/06/2005 - "Moreover, BS-RNase monomers described herein are more toxic to human tumor cells than is any known variant or homologue of RNase A including Onconase, an amphibian homologue in phase III clinical trials for the treatment of unresectable malignant mesothelioma."
5.	Thyroid Neoplasms (Thyroid Cancer) 06/01/2003 - "The caspase inhibitor Z-Val-Ala-Asp-(OMe)-fluoromethylketone protected thyroid cancer cells from BS-RNase-induced apoptosis. " 03/01/2001 - "The cytotoxic effects of bovine seminal ribonuclease (BS-RNase) against thyroid carcinoma cell lines with different degrees of differentiation in comparison to non-malignant cells, including human foreskin fibroblasts (HFF) and retinal pigment epithelial cells (RPE), were tested using the MTT dye reduction assay. "

Related Drugs and Biologics

1.	Ribonucleases (Ribonuclease)
2.	Pancreatic Ribonuclease (Ribonuclease A)
3.	Enzymes
4.	ranpirnase (Pannon)
5.	ribonuclease SPL
6.	Proteins (Proteins, Gene)
7.	Polymers
8.	Caspases
9.	Protein Isoforms (Isoforms)
10.	Solutions

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Withholding Treatment
3.	Injections