01/01/1984 - "M6434 improved the survival rate of rabbits in hemorrhagic shock. "
03/01/1989 - "Mechanisms involved in the effect of M6434 on experimental hemorrhagic shock: II. Effects on energy metabolism and organ blood flow."
03/01/1989 - "Mechanisms involved in the effect of M6434 on experimental hemorrhagic shock: I. Effects on myocardial contractility and venous return."
03/01/1989 - "Dopamine had no effect at 20 micrograms/kg/min, but it increased venous return in both states at 50 micrograms/kg/min. These results suggest that M6434 may improve the hemodynamic derangement in severe hemorrhagic shock through decreasing venous blood pooling."
|2.||Orthostatic Hypotension (Postural Hypotension)
11/01/1992 - "These results show that M6434 possesses a potent hypertensive effect with a weaker bradycardiac action and suggest that M6434 may be a potential candidate for an anti-hypotensive agent that can prevent the deterioration of hemodynamics in postural hypotension."
11/01/1992 - "In the postural hypotension of anesthetized dogs, M6434 at the doses more than 10 micrograms/kg, i.v. also produced the preventive effects on mean blood pressure and cerebral tissue blood flow. "
11/01/1992 - "We examined the effects of M6434 on mean blood pressure and heart rate in conscious rabbits and dogs and on experimental models of postural hypotension in conscious rabbits and anesthetized dogs. "
11/01/1992 - "[Effects of M6434, an orally active alpha 1-adrenoceptor agonist, on experimental postural hypotension in rabbits and dogs]."
06/01/1992 - "These results suggest that M6434 possesses a potent antihypotensive activity which is superior to that of midodrine, and M6434 may be useful in the treatment of essential and postural hypotension."
03/01/1989 - "To elucidate the mechanisms of protective effect of M6434 on experimental shock, the authors examined the effects of this compound on the survival time and hemodynamic changes in severely hemorrhagic-shocked dogs. "
01/01/1984 - "These results indicate that M6434 may be evaluated as a possible therapeutic agent for shock."
03/01/1989 - "M6434 (20 micrograms/kg/min) increased the venous return of dogs with cardiopulmonary bypass in both shock and normal state. "
03/01/1989 - "We also examined the effects of M6434 on contractile tension of isolated canine ventricular strips and on venous return in dogs with cardiopulmonary bypass in normal and shock state. "
01/01/1984 - "Effects of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434) on hemorrhagic, cardiogenic, and endotoxin shock in rats and rabbits."
|3.||Adenosine Triphosphate (ATP)
|2.||Cardiopulmonary Bypass (Heart-Lung Bypass)