amosulalol

05/01/1988 - "In our patient, both YM-09538 and bunazosin were effective in controlling severe hypertension preoperatively. "
01/01/1992 - "The results indicate that amosulalol is effective in the treatment of hypertension in non-insulin dependent diabetics and does not affect glucose and lipid metabolism."
05/01/1985 - "Repeated oral administrations of amosulalol and labetalol (50 mg/kg/day, b.i.d., for 12 weeks) produced not only an antihypertensive effect without evidence of tolerance, but also reductions in plasma renin activity (PRA) and heart rate in SHR with established hypertension. "

01/01/1992 - "In this open study, 41 hypertensive patients with non-insulin dependent diabetes mellitus were treated with the combined alpha- and beta-adrenoceptor blocker amosulalol hydrochloride for 24 weeks, either alone or added to existing antihypertensive therapy. "

11/01/1994 - "Oral administration of amosulalol (1-30 mg/kg) produced a dose-dependent antihypertensive effect without reflex tachycardia in conscious spontaneously hypertensive rats (SHR) with a duration > 10 h after the higher doses (10 and 30 mg/kg). "
07/01/1982 - "Intravenous administration of YM-09538 (10-100 micrograms/Kg) caused hypotension without tachycardia, but was accompanied with bradycardia in anesthetized dogs. "
11/01/1994 - "Amosulalol exerted antihypertensive activity without tachycardia through blockade of vascular alpha- and cardiac beta-adrenoceptors, and its activities were constant even after repeated p.o. "
05/01/1985 - "Amosulalol and labetalol did not increase heart rate, whereas prazosin induced a tachycardia in the hypertensive rats. "
11/01/1994 - "Oral (p.o.) administration of amosulalol 10 mg/kg produced equally potent reductions in mean arterial BP (MBP) without reflex tachycardia in deoxycorticosterone acetate-salt rats (DHR) and renal hypertensive rats (RHR) as it did in SHR. "

08/01/1986 - "The results indicate that the vascular alpha 1- and cardiac beta 1-adrenoceptor blocking activities of the optical isomers of amosulalol contribute to their hypotensive and bradycardia, respectively. "
07/01/1982 - "Intravenous administration of YM-09538 (10-100 micrograms/Kg) caused hypotension without tachycardia, but was accompanied with bradycardia in anesthetized dogs. "
08/01/1986 - "In contrast, (-)-amosulalol having a more potent beta 1-adrenoceptor antagonist activity than (+)-amosulalol and YM-11133 only produced dose-dependent bradycardia at the hypotensive doses. "

01/01/1991 - "Failure of blood pressure control by a new combined alpha- and beta-blocking agent (amosulalol) in a patient with pheochromocytoma."
01/01/1991 - "A 42-year-old woman with pheochromocytoma received preoperatively a combined alpha- and beta-adrenoceptor blocking agent, amosulalol, exerting some inhibitory action on both receptors. "