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amosulalol
RN given is for mono-HCl; structure given in first source
Also Known As:
5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide; YM 09538; YM-09538
Networked:
11
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Ethanolamines: 16
amosulalol: 11
Amides: 2428
Sulfonamides: 2809
Benzenesulfonamides: 153
amosulalol: 11
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzenesulfonamides: 153
amosulalol: 11
Alcohols: 595
Ethanol: 23169
Ethanolamines: 16
amosulalol: 11
Amino Alcohols: 20
Ethanolamines: 16
amosulalol: 11
Sulfur Compounds: 278
Sulfones: 534
Sulfonamides: 2809
Benzenesulfonamides: 153
amosulalol: 11
Related Diseases
1.
Hypertension (High Blood Pressure)
05/01/1988 - "
In our patient, both YM-09538 and bunazosin were effective in controlling severe hypertension preoperatively.
"
01/01/1992 - "
The results indicate that amosulalol is effective in the treatment of hypertension in non-insulin dependent diabetics and does not affect glucose and lipid metabolism.
"
05/01/1985 - "
Repeated oral administrations of amosulalol and labetalol (50 mg/kg/day, b.i.d., for 12 weeks) produced not only an antihypertensive effect without evidence of tolerance, but also reductions in plasma renin activity (PRA) and heart rate in SHR with established hypertension.
"
2.
Type 2 Diabetes Mellitus (MODY)
01/01/1992 - "
In this open study, 41 hypertensive patients with non-insulin dependent diabetes mellitus were treated with the combined alpha- and beta-adrenoceptor blocker amosulalol hydrochloride for 24 weeks, either alone or added to existing antihypertensive therapy.
"
3.
Tachycardia (Tachyarrhythmias)
11/01/1994 - "
Oral administration of amosulalol (1-30 mg/kg) produced a dose-dependent antihypertensive effect without reflex tachycardia in conscious spontaneously hypertensive rats (SHR) with a duration > 10 h after the higher doses (10 and 30 mg/kg).
"
07/01/1982 - "
Intravenous administration of YM-09538 (10-100 micrograms/Kg) caused hypotension without tachycardia, but was accompanied with bradycardia in anesthetized dogs.
"
11/01/1994 - "
Amosulalol exerted antihypertensive activity without tachycardia through blockade of vascular alpha- and cardiac beta-adrenoceptors, and its activities were constant even after repeated p.o.
"
05/01/1985 - "
Amosulalol and labetalol did not increase heart rate, whereas prazosin induced a tachycardia in the hypertensive rats.
"
11/01/1994 - "
Oral (p.o.) administration of amosulalol 10 mg/kg produced equally potent reductions in mean arterial BP (MBP) without reflex tachycardia in deoxycorticosterone acetate-salt rats (DHR) and renal hypertensive rats (RHR) as it did in SHR.
"
4.
Bradycardia
08/01/1986 - "
The results indicate that the vascular alpha 1- and cardiac beta 1-adrenoceptor blocking activities of the optical isomers of amosulalol contribute to their hypotensive and bradycardia, respectively.
"
07/01/1982 - "
Intravenous administration of YM-09538 (10-100 micrograms/Kg) caused hypotension without tachycardia, but was accompanied with bradycardia in anesthetized dogs.
"
08/01/1986 - "
In contrast, (-)-amosulalol having a more potent beta 1-adrenoceptor antagonist activity than (+)-amosulalol and YM-11133 only produced dose-dependent bradycardia at the hypotensive doses.
"
5.
Pheochromocytoma
01/01/1991 - "
Failure of blood pressure control by a new combined alpha- and beta-blocking agent (amosulalol) in a patient with pheochromocytoma.
"
01/01/1991 - "
A 42-year-old woman with pheochromocytoma received preoperatively a combined alpha- and beta-adrenoceptor blocking agent, amosulalol, exerting some inhibitory action on both receptors.
"
Related Drugs and Biologics
1.
Insulin (Novolin)
2.
Glucose (Dextrose)
3.
bunazosin (Andante)
4.
Adrenergic Receptors (Adrenergic Receptor)
5.
Antihypertensive Agents (Antihypertensives)
6.
Salts
7.
Renin
8.
Propranolol (Inderal)
9.
Prazosin (Minipress)
10.
Phentolamine (Z-Max)
Related Therapies and Procedures
1.
Therapeutics
2.
Oral Administration
3.
Intravenous Administration