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11-oxahomoaminopterin

structure given in first source

Also Known As:

L-Glutamic acid, N-(4-(2-(2,4-diamino-6-pteridinyl)ethoxy)benzoyl)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Aminopterin: 248
        11-oxahomoaminopterin: 1

Related Diseases

1.

09/01/1981 - "Although 11-oxahomoaminopterin showed antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR, it was inactive against L-1210 leukemia in mice at a maximum dose of 48 mg/kg. Compound Lactobacillus casei DHFR, it was inactive against L-1210 leukemia in mice at a maximum dose of 48 mg/kg. Compound 1 was also tested for its ability to be transported via the methotrexate transport system using the L-1210 and Ehrlich tumor cell lines, and these results are compared with those of related analogues. "

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Folic Acid Antagonists
3.	Folic Acid (Vitamin M)