neocarzinostatin chromophore

nonprotein chromophore of neocarzinostatin; antibiotic activity of Neocarzinostatin depends on wholy on chromophore interaction with DNA; Chrom A & Chrom B are separated by HPLC; Chrom C is derived from Chrom A; Chrom D is inactive minor component

Also Known As:

NCS-Chrom; NCS-Chrom A; NCS-Chrom B; NCS-Chrom C; NCS-Chrom D

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Enediynes: 19
        Zinostatin: 242
        neocarzinostatin chromophore: 3
    - Alkynes: 217
      - Polyynes: 10
        Diynes: 3
        Enediynes: 19
        Zinostatin: 242
        neocarzinostatin chromophore: 3

Experts

1.	Adhikari, Ajeeth: 1 article (01/2021)
2.	Rader, Christoph: 1 article (01/2021)
3.	Shen, Ben: 1 article (01/2021)
4.	Bingham, John P: 1 article (06/2003)
5.	Caddick, Stephen: 1 article (06/2003)
6.	Frost, Lisa M: 1 article (06/2003)
7.	Hartley, John A: 1 article (06/2003)
8.	Kelland, Lloyd R: 1 article (06/2003)
9.	Urbaniak, Michael D: 1 article (06/2003)
10.	Woolfson, Derek N: 1 article (06/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Since the isolation and structural determination of the neocarzinostatin chromophore in 1985, the enediynes have attracted considerable attention for their value as DNA damaging agents in cancer chemotherapy. "
2.	Leukemia 06/16/2003 - "Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. "
3.	Dehydration (Water Stress) 04/03/2002 - "A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation."

Related Drugs and Biologics

1.	Enediynes
2.	Uracil
3.	Sulfhydryl Compounds (Thiols)
4.	RNA (Ribonucleic Acid)
5.	Oxygen (Dioxygen)
6.	Mercaptoethanol (2 Mercaptoethanol)
7.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)