|1.||Mitchell, Timothy J: 14 articles (01/2014 - 02/2002)|
|2.||Paton, James C: 12 articles (07/2015 - 07/2002)|
|3.||Nau, Roland: 9 articles (01/2013 - 11/2002)|
|4.||Andrew, Peter W: 9 articles (04/2010 - 02/2002)|
|5.||Kadioglu, Aras: 8 articles (05/2015 - 06/2002)|
|6.||Mitchell, Tim J: 8 articles (02/2012 - 01/2002)|
|7.||Marquart, Mary E: 7 articles (01/2013 - 06/2007)|
|8.||Moore, Quincy C: 6 articles (01/2013 - 04/2007)|
|9.||Sanders, Melissa E: 6 articles (01/2013 - 06/2007)|
|10.||Norcross, Erin W: 6 articles (01/2013 - 01/2008)|
03/01/2001 - "This study examined the hypothesis that human antibody to pneumolysin provides protection against pneumococcal infection. "
03/01/2001 - "Protection against bacteremic pneumococcal infection by antibody to pneumolysin."
05/01/2015 - "Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection."
07/15/2014 - "We found that primary human monocyte-derived macrophages as well as THP-1 macrophages produced MIF upon pneumococcal infection in a pneumolysin-dependent manner. "
09/01/2011 - "Stimulation of CCL2 by macrophages upon pneumococcal infection alone required the pattern recognition receptor Nod2 and expression of the pore-forming toxin pneumolysin. "
04/01/2010 - "Carriage of D39 wildtype pneumococci restricted to the nasopharynx could be detected for at least 28 days post-infection, whereas nasopharyngeal carriage of a pneumolysin negative isogenic mutant (PLN-A) was cleared in 7-14 days. "
12/08/2000 - "PspA and pneumolysin have been shown to elicit protection against invasive infections. "
09/01/1999 - "Although further evaluation is required to assess the significance of pneumolysin detection in relation to carriage and infection and to devise a more suitable test format, these preliminary studies suggest that pneumolysin detection is a promising new approach to the non-cultural diagnosis of pneumococcal chest infection."
01/01/2013 - "High-speed video microscopy and live-cell imaging showed that the apical infection with both wildtype and pneumolysin-deficient pneumococci caused insufficient fluid flow along the epithelial surface and loss of efficient clearance, whereas ciliary beat frequency remained within the normal range. "
06/01/2012 - "Pneumolysin (Ply) is an essential virulence factor of S. pneumoniae, which can induce apoptosis in a variety of host cells to facilitate infection of pathogenic bacteria by as yet unclear mechanisms. "
07/01/2011 - "We further found that NLRP3 was beneficial for mice during pneumonia caused by pneumococci expressing hemolytic pneumolysin and was involved in cytokine production and maintenance of the pulmonary microvascular barrier. "
01/01/2008 - "TLR2 KO mice displayed a strongly reduced early inflammatory response in their lungs during pneumonia caused by both pneumolysin-producing and pneumolysin-deficient pneumococci. "
07/01/2007 - "A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. "
12/01/2006 - "A quantitative real-time polymerase chain reaction (PCR) method targeting the pneumolysin gene of Streptococcus pneumoniae in sputum specimens from patients with community-acquired pneumonia (CAP) was evaluated for the identification of pneumococci. "
12/01/2002 - "One hundred two samples of pleural fluid (51 samples from consecutive adult patients with pneumonia and 51 samples from unselected control subjects) were tested by the nested-PCR method to detect selected pneumolysin gene of S pneumoniae, and the results were compared with those provided by alternative diagnostic methods. "
03/04/2009 - "We aimed to assess the efficacy of a pneumococcal conjugate vaccine against acute otitis media (AOM) positive by pneumolysin-PCR (Ply-PCR). "
03/01/2004 - "In the present study, we compared the results of polymerase chain reaction (PCR) based on the amplification of the pneumolysin gene with the results of pneumococcal culture, for 2595 MEF samples obtained during AOM events in 831 children who were followed from 2-24 months of age in the Finnish Otitis Media Vaccine Trial. "
04/01/1996 - "Results suggest that pneumococcal otitis media pathogenesis is triggered principally by the inflammatory effects of intact and lytic cell wall products in the middle ear, with at most a modes additional pneumolysin effect. "
03/01/1996 - "Both the samples with culturable Pnc and with positive pneumolysin PCR increased with shorter duration of OME and a greater number of acute otitis media during the preceding 6 months. "
12/01/2012 - "Among 90 MEF culture negative samples from acute otitis media pediatric patients, 8.8% pneumolysin-PCR positivity was detected, demonstrating the sensitivity and reliability of PCR for rapid pneumonia evaluation. "
12/01/2012 - "Screening of pneumococcal pneumonia by amplification of pneumolysin gene in children visiting hospitals in lahore, pakistan."
06/01/2012 - "Streptococcus pneumoniae pneumolysin (PLY) is a virulence factor that causes toxic effects contributing to pneumococcal pneumonia. "
07/01/2011 - "The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia."
11/01/2007 - "The persistence of pneumolysin in urine of pneumococcal pneumonia patients decreased significantly after 4 to 6 days of treatment. "
01/01/2007 - "The cytotoxic and inflammatory properties of pneumolysin (PLY) have been implicated in the pathogenesis of pneumococcal pneumonia. "
|1.||pneumococcal surface protein A
|2.||N-Acetylmuramoyl-L-alanine Amidase (Autolysin)
|4.||Toll-Like Receptor 4
|7.||HSP40 Heat-Shock Proteins
|9.||Adenosine Triphosphate (ATP)
|2.||Positive-Pressure Respiration (PEEP)