involucrin

soluble precursor protein of cross-linked envelope characteristic of epidermal s. corneum synthesized by keratinocytes in natural & cultured human epithelia; see also related records for prekeratin & stratum corneum basic protein precursor

Also Known As:

Networked: 288 relevant articles (7 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Watt, F M: 3 articles (08/2001 - 12/2000)
2.	Fölster-Holst, Regina: 2 articles (10/2021 - 06/2004)
3.	Neumann, Claudia: 2 articles (10/2021 - 06/2004)
4.	Li, Wei: 2 articles (01/2021 - 07/2013)
5.	Furue, Masutaka: 2 articles (07/2020 - 03/2014)
6.	Gibbs, S: 2 articles (01/2020 - 01/2017)
7.	Limandjaja, G C: 2 articles (01/2020 - 01/2017)
8.	Niessen, F B: 2 articles (01/2020 - 01/2017)
9.	Scheper, R J: 2 articles (01/2020 - 01/2017)
10.	Teh, Muy-Teck: 2 articles (01/2020 - 01/2012)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/2013 - "In this study, we determined the immunolocalization of involucrin in psoriatic lesions and normal skin of individuals without psoriasis by means of immunofluorescence (IF) assay. " 06/01/2004 - "In this study, it is demonstrated that involucrin enhancer/promoter-dependent expression of human AR (INV-AR) in the suprabasal epidermis of transgenic mice also produces a cutaneous psoriasis-like phenotype. " 01/01/2023 - "Involucrin would be detectable in psoriasis, but it is absent in ILVEN. " 03/01/2015 - "In psoriasis, there is increased expression of involucrin, which leads to abnormal keratinocyte differentiation and hence to the formation of psoriatic plaques. " 03/01/2009 - "Dense genotyping of single-nucleotide polymorphism-tagging candidate genes within the epidermal differentiation complex revealed significant association in the proximity of the involucrin gene (IVL); the strongest association was seen in early-onset psoriasis patients (P=0.0014). "
2.	Skin Diseases (Skin Disease) 04/01/1997 - "To study the role of IFN-gamma in the pathogenesis of inflammatory skin diseases, we used the involucrin promoter to overexpress IFN-gamma in the suprabasal layers of transgenic mouse epidermis. " 06/15/1999 - "We have previously shown that female transgenic mice expressing IFN-gamma in the epidermis, under the control of the involucrin promoter, develop inflammatory skin disease and a form of murine lupus. " 01/01/1989 - "In this dermatosis, mediant lectins and involucrin to establish keratinocytes alteration. " 09/01/2005 - "Involucrin is one of the precursor proteins of the cornified cell envelope (CE) and is markedly increased in inflammatory skin diseases such as psoriasis. " 08/01/1997 - "In the present study, keratin and involucrin expression were studied in cutaneous lesions of discoid lupus erythematosus and lichen planus in order to gain a better understanding of the abnormal differentiation or maturation of the epidermal cells in these dermatoses. "
3.	Dermatitis 10/01/2022 - "In Vivo Imaging of CD8+ T-Cell‒Mediated Keratinocyte Apoptosis in Graft-Versus-Host Disease‒Like Dermatitis in Involucrin Membrane-Bound Ovalbumin Mice." 02/01/1993 - "In contrast to involucrin, loricrin expression was consistently down-regulated in agranulotic, parakeratotic keratinization as observed in psoriasis, dermatitis, pityriasis lichenoides, porokeratosis, or precancerous and malignant squamous lesions. " 09/01/2023 - "Kaempferol therapy improved the decreased expressions of filaggrin, loricrin, and involucrin in MC903-induced dermatitis skin site. " 09/01/2023 - "A histopathological study was performed to examine thymic stromal lymphopoietin expression, cornified envelope proteins such as filaggrin, loricrin, and involucrin, and the numbers of infiltrating inflammatory cells, including lymphocytes, macrophages, and mast cells in the dermatitis area. "
4.	Breast Neoplasms (Breast Cancer) 01/01/1997 - "Both squamoid features and involucrin expression, which were considered to be derived either from differentiation into keratinocytes or from some kind of cellular degeneration caused by high turnover rate, are suggested to influence the biological behaviour of breast cancer cells in vivo, and they may be effective in predicting the most likely recurrence sites." 01/01/1993 - "Involucrin expression in breast carcinomas: an immunohistochemical study." 06/28/2023 - "As some breast carcinomas have previously been shown to express high levels of involucrin, a marker of keratinocyte differentiation, we hypothesised that some breast tumours may de-differentiate to a keratinocyte-derived 'evolutionary history'. " 01/01/1997 - "In parallel with a histological review of squamoid features, we immunohistochemically investigated the expression of involucrin, a marker of terminal squamous differentiation, in 223 breast carcinomas with one to three regional nodal metastases but no distant metastases and analysed their association with other clinicopathological parameters to explore their clinical and biological implications. " 01/01/1997 - "Squamoid features and expression of involucrin in primary breast carcinoma associated with high histological grade, tumour cell necrosis and recurrence sites."
5.	Wounds and Injuries (Trauma) 01/01/2017 - "In vivo treatment of artificial human wounds with Vivostat PRF revealed a significant induction of involucrin and transglutaminase-1 gene expression. " 12/01/2000 - "In the hyperproliferative epidermis of healing wounds involucrin was expressed in most of the suprabasal layers. " 11/01/1999 - "The new observation that involucrin-positive cells can indeed migrate suggests that these cells may also contribute to wound re-epithelialization in vivo." 11/01/1999 - "Because electric fields are endogenous in skin wounds, it is likely that both the basal, involucrin-negative cells and the involucrin-positive suprabasilar cells respond to this cue with directional migration. " 10/01/1996 - "Involucrin was detected in the suprabasal regions of the migrating epidermis and thereafter in the upper half of neo-epidermis in the air-liquid incubated wound. "

Related Drugs and Biologics

1.	Filaggrin Proteins
2.	loricrin
3.	Proteins (Proteins, Gene)
4.	Cadherins (E-Cadherin)
5.	Cytokines
6.	Caspase 14
7.	S100 Calcium Binding Protein A7
8.	Peptides (Polypeptides)
9.	Caspase 3 (Caspase-3)
10.	Chemokines

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Subcutaneous Injections
4.	Intravenous Injections
5.	Hysterectomy