|1.||Quirico-Santos, Thereza: 9 articles (12/2013 - 01/2006)|
|2.||da Fonseca, Clovis Orlando: 7 articles (08/2012 - 05/2005)|
|3.||Chen, Thomas C: 6 articles (03/2015 - 11/2012)|
|4.||Gattass, Cerli Rocha: 6 articles (09/2008 - 05/2005)|
|5.||Schönthal, Axel H: 5 articles (03/2015 - 11/2012)|
|6.||Futuro, Débora: 5 articles (02/2011 - 12/2006)|
|7.||Wang, Weijun: 4 articles (03/2015 - 11/2012)|
|8.||Hofman, Florence M: 4 articles (03/2015 - 11/2012)|
|9.||Cho, Hee-Yeon: 4 articles (03/2015 - 11/2012)|
|10.||Hentosh, Patricia: 4 articles (08/2013 - 09/2007)|
07/26/2002 - "The monoterpene perillyl alcohol (POH) is a naturally occurring anti-cancer compound which is effective against a variety of rodent organ-specific tumor models. "
01/01/2006 - "The monoterpene perillyl alcohol (POH) has preventive and therapeutic effects in a wide variety of preclinical tumor models and is currently under phase I and phase II clinical trials. "
05/01/2005 - "The monoterpene perillyl alcohol (POH) has preventive and therapeutic effects in a wide variety of pre-clinical tumor models and is currently under phase I and II clinical trials. "
09/01/2004 - "Perillyl alcohol (POH) elicited anticarcinogenic effects in a number of cancer models and pharmacokinetic studies in humans revealed that PA is the major circulating metabolite following POH administration. "
09/19/2003 - "Perillyl alcohol (POH) is a naturally occurring monoterpene that has been shown to possess chemotherapeutic as well as chemopreventive activity in animal tumor models and is currently in Phase I and Phase II clinical trials. "
12/01/2013 - "Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation."
01/01/2013 - "The cohort included 95 patients with recurrent malignant glioma included in a Phase I/II clinical trial with perillyl alcohol and 100 matched healthy control subjects. "
01/01/2013 - "Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy."
02/01/2011 - "The monoterpene perillyl alcohol (POH) a Ras inhibitor with potential capacity to arrest gliomagenesis is being used in a phase I/II clinical trial in adults with recurrent malignant glioma. "
01/01/2006 - "Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol."
|3.||Glioblastoma (Glioblastoma Multiforme)
02/01/2011 - "Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma."
01/07/2011 - "Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol."
03/10/2010 - "Perillyl alcohol (POH) is a naturally occurring terpene and a promising chemotherapeutic agent for glioblastoma multiform; yet, little is known about its molecular effects. "
03/10/2010 - "Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol."
01/01/2009 - "Its usefulness is demonstrated by applying it to help interpret the effects of perillyl alcohol, a natural chemotherapeutic agent, on glioblastoma multiform cell lines (A172). "
01/01/1999 - "R-(+)-perillyl alcohol-induced cell cycle changes, altered actin cytoskeleton, and decreased ras and p34(cdc2) expression in colonic adenocarcinoma SW480 cells."
08/01/1997 - "Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells."
08/01/1997 - "We report that the rate of apoptosis is over 6-fold higher in perillyl alcohol-treated pancreatic adenocarcinoma cells than in untreated cells, and that the effect of perillyl alcohol on pancreatic tumor cells is significantly greater than its effect on non-malignant pancreatic ductal cells. "
02/01/1997 - "Perillyl alcohol at the 1-g/kg level significantly inhibited the incidence (percentage of animals with tumors) and multiplicity (tumors/ animals) of invasive adenocarcinomas of the colon, whereas perillyl alcohol at 2 g/kg diet inhibited the incidence of total adenocarcinomas of the colon and small intestine as compared to the control diet. "
09/01/2007 - "Perillyl alcohol and genistein suppressed 4E-BP1(Ser65) phosphorylation in prostate tumor cell lines, DU145 and PC-3, and in Caco2 adenocarcinoma cells. "
|5.||Breast Neoplasms (Breast Cancer)
04/01/2004 - "Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo."
05/01/2014 - "However, when it was tested in clinical trials for activity against brain metastases of breast cancer, the results were mixed and ranged from "encouraging activity" to "no objective responses." In an effort to generate an agent with greater activity against intracranial breast metastases, we synthesized a TMZ analog where the natural product perillyl alcohol (POH) was covalently linked to TMZ's amide functionality. "
10/01/1999 - "Induction of AP-1 activity by perillyl alcohol in breast cancer cells."
01/01/1996 - "Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer."
05/01/2014 - "A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo."
|3.||perilla alcohol (perillyl alcohol)
|8.||DNA (Deoxyribonucleic Acid)
|3.||Drug Therapy (Chemotherapy)