cupferron

superoxide dismutase inhibitor; RN given refers to parent cpd; structure

Also Known As:

N-nitroso-N-phenylhydroxylamine; N-nitroso-N-phenylhydroxylamine ammonium salt; hydrogen cupferron; azane; N-hydroxy-N-phenylnitrous amide

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - cupferron: 7

Experts

1.	Ford, Peter C: 1 article (12/2015)
2.	Garcia, John V: 1 article (12/2015)
3.	Levy, Elizabeth S: 1 article (12/2015)
4.	Morales, Demosthenes P: 1 article (12/2015)
5.	Reich, Norbert O: 1 article (12/2015)

Related Diseases

1.	Chromosome Aberrations (Chromosome Abnormalities) 06/01/1959 - "Studies on the production of chromosomal aberrations by visible light: the effects of cupferron, nitric oxide and wavelength." 05/25/1959 - "Cyanide, azide, and cupferron, which strongly inhibited respiration, also increased the frequencies of chromosome aberrations produced by x-rays at low oxygen pressures. " 05/25/1959 - "Nitrosophenylhydroxylamine-ammonium (cupferron), potassium cyanide, sodium azide, ethylenediaminetetraacetate (EDTA), alpha,alpha'-dipyridyl, and o-phenanthroline were tested (1) for their ability to enhance the frequencies of chromosomal aberrations produced by x-rays in the root tip cells of the broad bean, Vicia faba, and (2) for their ability to inhibit oxygen consumption of excised roots of the same plant. "
2.	Prostatic Neoplasms (Prostate Cancer) 12/28/2015 - "We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. "
3.	Neoplasms (Cancer) 05/15/1962 - "Rapid development of the tumor after inoculation with cupferron]."
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/1978 - "There were significant positive associations between the concentrations of cupferron administered to male and female rats and the incidences of: squamous-cell carcinomas of the forestomach, hepatocellular carcinomas and neoplastic nodules, and hemangiosarcomas. " 01/01/1978 - "Under the conditions of this bioassay cupferron was carcinogenic in Fischer 344 rats, causing hemangiosarcomas, hepatocellular carcinomas, and squamous-cell carcinomas of the forestomach in males and females as well as carcinomas of the auditory sebaceous gland in females. "
5.	Hemolysis 10/04/2023 - "Cupferron cytotoxicity was checked via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and hemolysis assays. "

Related Drugs and Biologics

1.	Nitric Oxide (Nitrogen Monoxide)
2.	Gold
3.	Ammonium Compounds
4.	Sodium Azide
5.	2,2'-Dipyridyl (2,2 Bipyridine)
6.	Sulfhydryl Compounds (Thiols)
7.	Solutions
8.	Potassium Cyanide
9.	Oxygen (Dioxygen)
10.	Edetic Acid (EDTA)

Related Therapies and Procedures

1.	Therapeutics
2.	Photothermal Therapy