succinic anhydride

12/28/2017 - "Compared with free DOX and DOX-conjugated EcN via stable linkers of succinic anhydride, the EcN-ca-Dox treatment improves the antitumor efficacy with respect to the tumor growth inhibition, prolongation of animal survivals, and apoptosis induction of tumor cells. "
01/01/2020 - "The coating polymer was mixed with a small amount of pHe-insensitive PEG-pAEMA modified with succinic anhydride (denoted as PPS), giving a balanced negatively charged and PEG-shielded surface with a pHe-responsive property for achieving the expected tumor-triggered enhanced gene delivery. "
06/25/2019 - "Carboxyl groups were introduced via modification with succinic anhydride for improved drug loading and folic acid (FA) ligands were incorporated for tumor targeting. "
01/01/2017 - "The carbon framework of cyclohelminthols I-IV is found at the C1-C8 propenylcyclopentene substructure of 1. Thus, 1 is assumed to be biosynthesized by cyclopropanation between an oxidized form of cyclohelminthol IV and a succinic anhydride derivative 4. Cytotoxicity for two cancer cell lines and proteasome inhibition efficiency are measured."
01/21/2020 - "The thermo-responsiveness and singlet oxygen generation of the loaded ICG in DMMA-modified PLL nanoparticles are comparable to those of free ICG under laser irradiation, which induces higher cytotoxicity to cancer cells compared to succinic anhydride (SA)-modified PLL nanoparticles that are not pH-responsive. "

04/01/2020 - "In order to ward off these infections, this paper explores the immobilization of triethoxysilylpropyl succinic anhydride (TESPSA, TSP) silane onto dental implants, and the interaction of two distinct monospecies biofilms and an oral plaque with the coated titanium samples. "
11/01/2019 - "The hypothesis of this work is that two distinctively different polymeric delivery systems, specifically D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-poly(lactic-co-glycolic acid) (PLGA) nanoparticles and octenyl succinic anhydride-modified low molecular weight hyaluronic acid (OSA-HA) nanogels may be used to substantially improve the properties of azithromycin, allowing its use for effective treatment of Pseudomonas aeruginosa biofilm infections. "

01/01/1990 - "NTP Toxicology and Carcinogenesis Studies of Succinic Anhydride (CAS No. 108-30-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)."
01/01/1990 - "NTP Toxicology and Carcinogenesis studies were conducted by administering suspensions of succinic anhydride (97% pure) in corn oil by gavage to groups of F344/N rats and B6C3F1 mice of each sex for 16 or 20 days, 13 weeks, or 2 years. "

01/01/1990 - "Necrosis and inflammation of the upper respiratory tract were seen in 3/10 male and 3/10 female rats given 750 mg/kg and 2/10 female rats given 375 mg/kg. In the 16-day studies in mice, doses of succinic anhydride given on 12 exposure days ranged from 219 to 3,500 mg/kg. All animals that received 875 mg/kg or higher doses of succinic anhydride died before the end of the studies. "

01/01/1990 - "Necrosis and inflammation of the upper respiratory tract were seen in 3/10 male and 3/10 female rats given 750 mg/kg and 2/10 female rats given 375 mg/kg. In the 16-day studies in mice, doses of succinic anhydride given on 12 exposure days ranged from 219 to 3,500 mg/kg. All animals that received 875 mg/kg or higher doses of succinic anhydride died before the end of the studies. "