|1.||Fahnestock, Margaret: 2 articles (12/2015 - 01/2015)|
|2.||Nicolini, Chiara: 2 articles (12/2015 - 01/2015)|
|3.||Sbarrato, T: 2 articles (01/2015 - 05/2014)|
|4.||Huang, Shile: 2 articles (08/2014 - 08/2013)|
|5.||Chen, Ji-Long: 2 articles (08/2014 - 08/2013)|
|6.||Bushell, M: 2 articles (05/2014 - 06/2001)|
|7.||Sonenberg, Nahum: 2 articles (10/2010 - 03/2010)|
|8.||Choi, Mi Ryoung: 1 article (05/2015)|
|9.||An, Chang Hyeok: 1 article (05/2015)|
|10.||Yoo, Nam Jin: 1 article (05/2015)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "Consistent with these data, modulation of eIF4A1, eIF4B and PCDC4 expression in cultured MCF7 cells all restricted breast cancer cell growth and cycling. "
09/01/2014 - "Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer."
01/01/2015 - "We found eIF4A1, eIF4B and eIF4E to be independent predictors of poor outcome in ER-negative disease, while in contrast, the eIF4A1 inhibitor PDCD4 was related to improved outcome in ER-positive breast cancer. "
01/01/2015 - "Therefore, immunohistochemical analysis was performed on over 3000 breast tumors to investigate the relationship among expression of eIF4A1, the helicase-modulating proteins eIF4B, eIF4E and PDCD4, and clinical outcome. "
08/01/2014 - "Taken together, our findings reveal that eIF4B plays an important role in host defense against IAV infection at least by regulating the expression of IFITM3, which restricts viral entry and thereby blocks early stages of viral production. "
06/01/1978 - "Inactivation of eIF-4B appears to be the mechanism by which poliovirus infection causes a selective inhibition of translation."
08/01/2014 - "Importantly, we observed that eIF4B knockdown transgenic mice were more susceptible to IAV infection, exhibiting faster weight loss, shorter survival time, and more-severe organ damage. "
08/01/2014 - "Here, we show that IAV infection induces lysosomal degradation of eIF4B protein; and eIF4B inhibits IAV replication by upregulating expression of interferon-induced transmembrane protein 3 (IFITM3), a key protein that protects the host from virus infection. "
11/01/2009 - "However, at 48 h post-infection, eIF4A, eIF4E, eIF4G1, eIF4G3, eIF4B, and eIF4E-BP3 were down-regulated, suggesting that cap-dependent translation could be inhibited during the progression of infection. "
|3.||Schizophrenia (Dementia Praecox)
10/01/2010 - "In summary, this study found that neonatal MK-801 treatment induced dysregulation in the p70S6K-S6/eIF4B pathway and protein translation in the frontal cortex of the developing rat brain, which may suggest an important role of protein translation machinery in the MK-801 neurodevelopmental animal model of schizophrenia."
11/01/2012 - "We next sought to evaluate mTOR as a GCT therapeutic target using the Pten (tm1Hwu/tmiHwu);Ctnnb1 (tm1Mmt/+);Amhr2 (tm3(cre)Bhr/+) (PCA) mouse model, in which mTOR, RPS6KB1, eIF4B and PPARG are upregulated in tumor cells in a manner similar to human GCT. "
10/15/2010 - "Taken together, these findings identify eIF4B as a potential target for development of anti-cancer therapies."
10/15/2010 - "Moreover, eIF4B depletion in cancer cells attenuates proliferation, sensitizes them to genotoxic stress-driven apoptosis. "
05/01/2014 - "Reducing eIF4B expression alone is sufficient to decrease synthesis of proteins associated with enhanced tumor cell survival, namely DAXX, BCL2 and ERCC5. "
08/01/2013 - "Taken together, our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes, and they highlight eIF4B as a candidate therapeutic target for treatment of Abl-induced cancers."
01/10/1997 - "Only the phosphorylation state of two factors, eIF-4A and eIF-4B, changed following a heat shock, suggesting that plants may differ significantly from animals in the way in which their translational machinery is modified in response to a thermal stress."
10/10/1984 - "Immunoblot analyses show that eIF-2 alpha and eIF-2 beta become modified during heat shock, and eIF-4B variants disappear. "
10/10/1984 - "In vitro assays for initiation factor activities reveal heat shock inhibits eukaryotic initiation factor 2 (eIF-2), eIF-(3 + 4F), and eIF-4B. "
01/10/1997 - "We have determined the isoelectric states for the wheat translation initiation factors eIF-4A, eIF-4B, eIF-4F, eIF-iso4F, and eIF-2 and the poly(A)-binding protein in the seed, during germination, and following heat shock of wheat seedlings using two-dimensional gel electrophoresis and Western analysis. "
|1.||Eukaryotic Initiation Factor-4E
|2.||70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
|3.||Proteins (Proteins, Gene)
|4.||Eukaryotic Initiation Factor-3
|5.||Dizocilpine Maleate (Dizocilpine)
|6.||Peptide Initiation Factors (Initiation Factor)
|7.||Poly(A)-Binding Proteins (Poly(A)-Binding Protein)
|8.||Eukaryotic Initiation Factor-2 (EIF 2)
|9.||Insulin Receptor Substrate Proteins
|10.||Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)