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naphthalene

structure in Merck Index, 9th ed, #6194
Networked: 382 relevant articles (13 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lotan, Reuben: 4 articles (07/2005 - 04/2002)
2. Yue, P: 4 articles (12/2000 - 09/2000)
3. Sun, S Y: 4 articles (12/2000 - 09/2000)
4. Lotan, R: 4 articles (12/2000 - 09/2000)
5. Buckpitt, Alan R: 3 articles (01/2015 - 04/2004)
6. Morin, Dexter: 3 articles (01/2015 - 06/2009)
7. Van Winkle, Laura S: 3 articles (05/2014 - 05/2002)
8. Clewell, Harvey J: 3 articles (05/2014 - 07/2008)
9. Gross, Elizabeth A: 3 articles (01/2012 - 03/2010)
10. Dodd, Darol E: 3 articles (01/2012 - 03/2010)

Related Diseases

1. Cataract (Cataracts)
2. Poisoning
3. Neoplasms (Cancer)
11/03/2005 - "Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells."
07/01/2008 - "Critical areas of uncertainty requiring resolution to enable improved human cancer risk assessment were considered to be that: (1) cytotoxic naphthalene metabolites, their modes of cytotoxic action, and detailed low-dose dose-response need to be clarified, including in primate and human tissues, and neonatal tissues; (2) mouse, rat, and monkey inhalation studies are needed to better define in vivo naphthalene uptake and metabolism in the upper respiratory tract; (3) in vivo validation studies are needed for a PBPK model for monkeys exposed to naphthalene by inhalation, coupled to cytotoxicity studies referred to above; and (4) in vivo studies are needed to validate a human PBPK model for naphthalene. "
02/01/2012 - "To address the question of human relevancy, a literature search for cancer case reports in workers exposed to naphthalene was performed, along with an evaluation of major studies from industries with naphthalene-containing streams having the highest naphthalene exposures and/or most extensive epidemiology data. "
07/01/2008 - "Studies demonstrating that naphthalene produces respiratory tract tumors in mice and rats raised the question of whether humans are at risk for cancer, at environmental or workplace concentrations of naphthalene. "
01/01/2016 - "A non-mutagenic threshold MoA for naphthalene-induced rat nasal tumors should be considered as a basis to determine human relevance and to guide regulatory and risk-management decisions. "
4. Glioma (Gliomas)
5. Atopic Dermatitis (Atopic Eczema)

Related Drugs and Biologics

1. Glutathione (Reduced Glutathione)
2. Cysteine (L-Cysteine)
3. Tretinoin (Retinoic Acid)
4. Acetaminophen (Paracetamol)
5. Galactose (Galactopyranose)
6. tolrestat
7. Adrenergic Receptors (Adrenergic Receptor)
8. Prodrugs
9. Mercaptoethanol (2 Mercaptoethanol)
10. zonular Cataract

Related Therapies and Procedures

1. Lenses
2. Aftercare (After-Treatment)
3. Intraperitoneal Injections
4. Blood Transfusion (Blood Transfusions)
5. Oral Administration